PURPOSE We aimed to determine the treatment of choice criteria for benign prostatic hyperplasia (BPH) by analyzing the factors causing alpha-adrenergic receptor blocker (alpha-blocker) monotherapy failure. MATERIALS AND METHODS This retrospective study enrolled 129 patients with BPH who were prescribed an alpha-blocker. Patients were allocated to a transurethral resection of prostate (TURP) g...

One ultimate goal of hypertension therapy is to cause permanent reversal ("regression") of already established hypertension. Our aim was to examine whether high-dose "pulse" treatment with a renin-angiotensin system inhibitor could cause regression of established hypertension and to link this action to reversal of arteriolar hypertrophy and changes in vascular matrix metalloproteinase activitie...

CONTEXT Recent epidemiologic studies have raised the concern that calcium channel blocker use may increase the risk of cancer overall and of several specific cancers. OBJECTIVE To assess whether calcium channel blocker use increases the risk of cancer overall and of specific cancers. DESIGN Case-control drug surveillance study based on data collected from 1983 to 1996. SETTING Hospitals i...

background: premature ejaculation (pe) is the most common sexual disorder in men and studies reported prevalence up to 30% (1, 2). pe is not a life-threatening medical condition but it influences the quality of life (qol). objectives the aim of this study was to compare the efficiency, and safety of alpha blocker drugs in the treatment of patients with premature ejaculation (pe). additionally w...

The morphologically diverse leafhopper tribe Hyalojassini is reinstated from synonymy under Iassini based on distinctive features of the male genitalia and a key to the Oriental genera is given. The previously monotypic genera Hyalojassus Evans and Coriojassus Evans are revised and redescribed based on study of the type species. The following new genera and species are described from Thailand a...

Objective: In this study, it was aimed to investigate the antinociceptive activity potential of Tofisopam and elucidate possible involvement opioid system in effect.Material Method: The efficacy (25 50 mg/kg) evaluated by hot-plate acetic acid-induced writhing tests; while effects drug on motor coordination mice were with Rota-rod tests.Result Discussion: at a dose mg/kg significantly prolonged...