BACKGROUND Judicious use of antibiotics can slow the spread of antimicrobial resistance. However, overall patterns of antibiotic use among ambulatory patients are not well understood. OBJECTIVE To study patterns of outpatient antibiotic use in the United States, focusing on broad-spectrum antibiotics. DESIGN Cross-sectional survey in three 2-year periods (1991-1992, 1994-1995, and 1998-1999...

OBJECTIVE To assess the effect of a clinical decision support system (CDSS) integrated into an electronic health record (EHR) on antibiotic prescribing for acute respiratory infections (ARIs) in primary care. MATERIALS AND METHODS Quasi-experimental design with nine intervention practices and 61 control practices in the Practice Partner Research Network, a network of practices which all use t...

CONTEXT Most sore throats are due to viral upper respiratory tract infections. Group A beta-hemolytic streptococci (GABHS), the only common cause of sore throat warranting antibiotics, is cultured in 5% to 17% of adults with sore throat. The frequency of antibiotic use for pharyngitis has greatly exceeded the prevalence of GABHS, but less is known about specific classes of antibiotics used. Onl...

BACKGROUND Early review of antimicrobial prescribing decisions within 48 h is recommended to reduce the overall use of unnecessary antibiotics, and in particular the use of broad-spectrum antibiotics. When parenteral antibiotics are used, blood culture results provide valuable information to help decide whether to continue, alter or stop antibiotics at 48 h. The objective of this study was to i...

OBJECTIVES The objectives of this study were to provide a nationally representative analysis of antibiotic prescribing in outpatient paediatrics and to assess overall and class-specific antibiotic costs in Greece. METHODS Data on antibiotic prescriptions for patients aged ≤19 years old between July 2010 and June 2013 in Greece were extracted from the IMS Health Xponent database. Antibiotics w...

BACKGROUND AND OBJECTIVE Nanoscopic life forms called Nanobacteria or calcifying nanoparticles (CNP) are unconventional agents. These novel organisms are very small (0.1 to 0.5 microns) and possess unusual properties such as high resistance to heat and routine antimicrobial agents. Nanobacteria are 100 times smaller than bacteria and protected by a shell of apatite, so they could be as candidat...

results the isolates were completely resistant to the tested antibiotics, with minimum inhibitory concentration (mic) values for ceftazidime, imipenem, and gentamicin between 256 to > 256 μg/ml, 8 to > 256 μg/ml, and 64 to > 256 μg/ml, respectively. the r. dentatus extract had a broad spectrum activity against all tested isolates and maximum growth inhibition against isolates from burn wound an...

The indiscriminate and injudicious administration of antibiotics and irrational treatment of bovine mastitis with different antibiotics have invited serious complications like multiple drug resistance. The present paper reports the microbiological examination and reporting of a clinical case of mastitis in cow and its recommended therapeutic management with the selected broad spectrum antibioti...