Background and objectives: Carvacrol is one of the main pharmacologically active components of Thymus vulgaris essential oil which has shown several therapeutic effects. There are few works regarding the formulation of essential oils as oral solid dosage forms due to their liquid nature, stability and technical problems. The aim of this study was to combine the solid-d...

Objective(s): This study evaluates the effect of substitution of microcrystalline cellulose (MCC) with ethylcellulose (EC) on mechanical and release characteristics of theophylline pellets. Materials and Methods: The effect of addition of EC was investigated on characteristics of pellets with varying drug content prepared by extrusion-spheronization. Also the effect of type of granulating liqui...

Rajesh Gandhi, PhD, is a senior research scientist in Ranbaxy Research Laboratories (Gurgaon, India), Yasvanth Ashokraj is a doctoral student, Chaman Lal Kaul, PhD, is the director of the National Institute of Pharmaceutical Education and Research (NIPER), and Ramesh Panchagnula, PhD, is a professor and head of the Department of Pharmaceutics, NIPER, Sector 67, S.A.S. Nagar (Punjab) 160062 Indi...

The purpose of this work was to introduce a new concept of coated pellets containing chitosan microspheres loaded with didadosine for oral administration, aiming at reducing the frequency of administration and improving the bioavailability by a suitable release profile. Chitosan microspheres were produced under fluidized bed, followed by extrusion and spheronization to obtain pellets with a mea...