Metastatic epidural compression of the spinal cord is a significant source of morbidity in patients with systemic cancer. With improved oncological treatment, survival in these patients is improving and metastatic cord compression is encountered increasingly often. The treatment is mostly palliative. Surgical management involves early circumferential decompression of the cord with concomitant s...

Delayed neurological deterioration in the absence of direct cord insult following surgical removal and cord decompression is a rare but severe postoperative complication in a small subset of patients with intraspinal meningiomas. To date, the underlying pathophysiology of such a finding remains unclear and ischemia-reperfusion injury (IRI) is considered as the potential etiology in the literatu...

STUDY DESIGN Experimental investigation of an acute thoracic spinal cord injury model in rats involving acute clip compression that simulates human injury. OBJECTIVE To assess the dose-response of this model for the relationship between the force of injury on the rat thoracic spinal cord and histological and functional outcome measures. SUMMARY OF BACKGROUND DATA Acute extradural clip compr...

background and aim : acute injuries of the spine and spinal cord are causing the greatest amount of disability. they produce high cost outcomes for patients and society psychologically and economically. knowing the epidemiology of these injuries play an important role in planning for prevention and conservative treatment. but now, we have little information about this in our country. the aim of...

Neurological degeneration can occur after compression of the spinal cord. It is widely accepted that spinal cord compression leads to ischemic lesions and ultimately neurological dysfunction due to a narrowed spinal canal. Therefore, an in-depth understanding of the pathogenesis of spinal cord compression injury is required to help develop effective clinical interventions. In the present study,...

Ossification of the posterior longitudinal ligament (OPLL) and ossification of the ligamentum flavum (OLF) have been recognized as causes of myelopathy due to thickening of the ligaments resulting in narrowing of the spinal canal and compression of the spinal cord. However, few studies have focused on predicting stress distribution under conditions of OPLL and OLF based on clinical aspects such...

MR imaging was performed on 21 patients who had high-grade myelographic block due to various diseases in all spinal compartments (extradural, intradural/extramedullary, and intramedullary) and in all portions of the spinal canal (cervical, thoracic, and lumbosacral). Loss of CSF pulsation artifacts due to significant compression of the spinal cord was demonstrated on non-motion-compensated T2-w...

BACKGROUND Metastatic spinal cord compression is a dreaded complication of cancer affecting 5-10% of patients requiring urgent treatment. A clinical practice improvement project was carried out to review and fine tune the clinical pathway for the acute management of patients with metastatic spinal cord compression. OBJECTIVE To improve the quality of care for metastatic spinal cord compressio...

Malignant spinal cord compression is a common oncological emergency. Three cases are presented to illustrate some important management aspects of malignant spinal cord compression. In general, the definitive treatment of malignant spinal cord compression depends on the patient’s performance status, the life expectancy and the type of malignancy. Radiotherapy is the mainstay of treatment. Single...