MPNs including a heterogeneous group of clonal or oligoclonal hamtopathies characterized by proliferation and accumulation of mature myeloid cells. JAK2 tyrosine kinase mutation is the most common molecular lesion identified in 90% of cases. JAK2 is involved in EPO signaling pathway, and mutations in it lead to EPO-independent spontaneous phosphorylation. Most tyrosine kinase inhibitors (TKI) a...

There are many types of tyrosine kinase involved in intracellular mitogenic mechanism, particularly, Tec tyrosine kinase are involved in apoptosis pathway. Tec tyrosine kinases do not have any transmembrane domain so it is known as non receptor tyrosine kinase. There are various types of Tec tyrosine kinase like Txk, Btk, Itk, Rik and Bmx. These kinases have different protein or domain structur...

A tyrosine-specific protein kinase of Mr 60,000 (TK-I) was purified to near homogeneity from the particulate fraction of rat spleen. The purification procedure involved sequential chromatography of the detergent-solubilized enzyme on DEAE-Sephacel and hydroxyapatite columns. Polyacrylamide-gel electrophoresis under denaturing conditions showed one major polypeptide, of Mr 60,000. Gel filtration...

The importance of B-cell activation and immune complex-mediated Fc-receptor activation in the pathogenesis of immunologically mediated glomerulonephritis has long been recognized. The two nonreceptor tyrosine kinases, spleen tyrosine kinase (Syk) and Bruton's tyrosine kinase (Btk), are primarily expressed by hematopoietic cells, and participate in B-cell-receptor- and Fc-receptor-mediated activ...

Spleen tyrosine kinase (SYK) has an important role in immunoreceptor signaling, and SYK inhibition has accordingly attenuated immune-mediated injury in several models. Therefore, the present study examined the effect of SYK inhibition with the selective spleen tyrosine kinase inhibitor P505-15 in experimental rheumatoid arthritis (RA) using a murine model of collagen-induced arthritis (CIA). Tr...