The centroidal Voronoi tessellation (CVT) has found versatile applications in geometric modeling, computer graphics, and visualization, etc. In this paper, we first extend the concept of CVT from Euclidean space to spherical space and hyperbolic space, and then combine all of them into a unified framework – the CVT in universal covering space. The novel spherical and hyperbolic CVT energy funct...

Several potent and selective A2A adenosine receptor agonists are currently available. These compounds have a high affinity for the A2A receptor and a long duration of action. However, in situations where a short duration of action is desired, currently available A2A receptor agonists are less than ideal. From a series of recently synthesized A2A receptor agonists, two agonists (CVT-3146 and CVT...

‘Non-excludability’ of skills is suspected to give rise to poaching externalities and cause under-investment in training. To substantiate this hypothesis, the paper at hand investigates the relationship between labor turnover and firms’ dedication to continuing vocational training (CVT) exploiting novel survey data on firms in Germany (BIBB-FluCT data, N = 1.238). Regression analyses of these d...

CVT-E002, a proprietary extract from North American ginseng (Panax quinquefolium) showed immunomodulating activity. Cytochrome P450 (CYP), UDP-glucuronosyl transferase (UGT), and glutathione S-transferase (GST) are important drug-metabolizing enzymes. Modulation of drugmetabolizing enzymes is a main cause of drug interactions. To assess the possible metabolism-based drug interaction of CVT-E002...

This article reports on the design, analysis and control of a new type of wheeled mobile robot based on a nonholonomic spherical continuously variable transmission (S-CVT). Our S-CVT based mobile robot is designed to increase the run time (i.e., the length of time in which the robot can be operated), and to achieve full planar accessibility with the design of a novel pivoting device that takes ...

Cerebral venous thrombosis (CVT) is an uncommon disease that mainly affects subjects younger than 40 years of age, patients with thrombophilia, and women who are pregnant or receiving hormonal contraceptives. The annual incidence is estimated to be 3 to 4 cases per million, which increases to 12 cases per 100 000 deliveries during the peripartum period. Mortality and recurrence rates are lower ...

BACKGROUND The parasympathetic nervous system has been implicated in the pathogenesis of a number of gastrointestinal disorders including irritable bowel syndrome. Within the field, cardiometric parameters of parasympathetic/vagal tone are most commonly derived from time, or frequency, domain analysis of heart rate variability (HRV), yet it has limited temporal resolution. Cardiac vagal tone (C...

There is substantial evidence in the literature that elevated plasma free fatty acids (FFA) play a role in the pathogenesis of type 2 diabetes. CVT-3619 is a selective partial A(1) adenosine receptor agonist that inhibits lipolysis and lowers circulating FFA. The present study was undertaken to determine the effect of CVT-3619 on insulin resistance induced by high-fat (HF) diet in rodents. HF d...

BACKGROUND AND PURPOSE Quantitative predictions of the risk of cerebral venous thrombosis (CVT) conferred by certain genotypes have yet to be reliably established. We conducted a comprehensive meta-analysis of all candidate genes studied to assess their genetic contribution to the etiology of CVT. We compared our findings against equivalent analyses for pediatric CVT and adult ischemic stroke. ...

Cerebral venous thrombosis (CVT) is an under diagnosed condition for acute or slowly progressive neurological deficit. CVT is less frequent than arterial thrombosis. CVT has a wide spectrum of signs and symptoms, which may evolve suddenly or over the weeks. It is clinically challenging and mimics many neurological conditions such as, meningitis, encephalopathy, benign intracranial hypertension,...