نتایج جستجو برای: spondylarthropathies
تعداد نتایج: 675 فیلتر نتایج به سال:
We describe a young woman who developed early and severe aortic regurgitation and subsequent aortitis with aneurysm formation requiring surgery.
Tumour necrosis factor (TNF)-a is currently being targeted in autoimmune joint diseases, including rheumatoid arthritis (RA) and spondylarthropathies [1, 2]. Widespread use of antiTNF-a therapies (e.g. etanercept) has unveiled a spectrum of adverse effects, including infection [3] and a systemic lupus erythematosus (SLE)-like syndrome [4]. The latter appears to be biologically based on perturba...
OBJECTIVES The recommended starting dose for infliximab for ankylosing spondylitis 5mg/kg is higher than that for rheumatoid arthritis. Because of the high expense of the drug lower doses may be considered. We report our experience with lower initial doses. METHODS Thirty patients with active SpA (16 psoriatic arthritis, 12 ankylosing spondylitis and 2 undifferentiated) received 6 infliximab ...
BACKGROUND Calpastatin is the natural inhibitor of calpains, a protease that is overexpressed in rheumatoid synovial tissue and plays a key role in cartilage destruction. Autoantibodies to calpastatin (ACAST) were recently detected in rheumatoid arthritis (RA). Our aim was to determine their prevalence and their clinical significance. METHODS ACAST were detected in a solid-phase enzyme-linked...
In a recent issue of the Annals our group reported the cases of two HLA-B27 positive patients who developed peripheral arthritis immediately after a significant traumatic episode.1 Unlike previously reported cases of HLA-B27 associated peripheral arthritis triggered by trauma24 they showed a rapid, severe destructive process. In the past few months both patients have had total hip replacement. ...
RATIONALE Anti-CCP antibodies are detectable not only in rheumatoid arthritis (RA), but also in psoriatic arthritis (PsA). It is possible those anti-CCP antibodies are associated with features of PsA and that these auto-antibodies are useful in distinguishing PsA from RA. OBJECTIVE to evaluate the prevalence and the associations of anti-CCP antibodies in PsA patients; to evaluate the usefulne...
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