A prostate cancer susceptibility locus ( HPC1 ) at 1q24-25 has been identified. Subsequent analysis showed that the majority of the evidence for localization was provided by families with relatively young (<65 years) average age at diagnosis. We examined evidence for linkage to this region in a set of 41 extended multi-case prostate cancer pedigrees containing 440 prostate cancer cases. Genotyp...

objective: prostate cancer is the fifth most common cancer. in 2012, it was the second leading cause of cancer death for men worldwide. the pi3k/akt pathway plays an essential role in pathogenesis of prostate cancer; the key role of this pathway in cancer progression makes it an attractive target for prostate cancer therapy. micrornas (mirnas) that regulate gene expression have a special abilit...

background: it is now well-demonstrated that histone demethylases play an important role in developmental controls, cell-fate decisions, and a variety of diseases such as cancer. lysine-specific demethylase 5d (kdm5d) is a male-specific histone demethylase that specifically demethylates di- and tri-methyl h3k4 at the start site of active genes. in this light, the aim of this study was to invest...

background: latent adenocarcinoma of prostate refers to cases who present no obvious sign or symptom during their life spans and the tumor is incidentally found at postmortem examination. its frequency can be very important in epidemiologic investigations, prevention and treatment. no previous study has been done in this regard in iran and the studies performed in other countries show various r...

normal 0 false false false en-us x-none ar-sa background: prostate cancer is one of the most common cancer types both in western and eastern countries, involving mostly elder men. the mechanisms underlying the prostate cancer development remain unclear. prostate-specific antigen (psa) is the only well accepted marker for prostate cancer diagnosis and prognosis. the diagnosis and treatment of pr...

prostate cancer is the second common form of cancer in men. detection of circulating prostate specific antigen (psa) transcripts has effectively been used for early diagnosis of prostate cancer cells. this investigation employed a reverse transcriptase polymerase chain reaction (rt-pcr) technique to distinguish the patients with either localized or metastatic prostate cancer (cap) vs. benign pr...

This review is focused on mouse models for prostate cancer that have been designed on the basis of genetic alterations that are frequently found in human prostate cancer. It begins with an analysis of the similarities and differences in the gross and microscopic anatomy of the mouse and human prostate glands, and extends to the pathologies induced in the genetically manipulated mouse prostate i...

BACKGROUND A mutation in the androgen receptor (AR) gene, namely AR R726L, was described in 2% of Finnish men with sporadic or familial prostate cancer and was associated with an approximately sixfold increased risk of prostate cancer. We set out to determine the incidence of this mutation in a sample of men with either early-onset and/or familial prostate cancer in the United States. METHODS...

BACKGROUND Rare, inherited mutations account for 5% to 10% of all prostate cancer cases. However, to date, few causative mutations have been identified. METHODS To identify rare mutations for prostate cancer, we conducted whole-exome sequencing (WES) in multiple kindreds (n = 91) from 19 hereditary prostate cancer (HPC) families characterized by aggressive or early-onset phenotypes. Candidate...