(6R)-l-erythro-5,6,7,8-Tetrahydrobiopterin (BH4) is an essential cofactor for monoamine and nitric oxide (NO) production. Sepiapterin reductase (SPR) catalyzes the final step in BH4 biosynthesis. We analyzed the cardiovascular function of adult Spr gene-disrupted (Spr-/-) mice for the first time. After weaning, Spr-/- mice suffered from hypertension with fluctuation and bradycardia, while the m...

In this study, we demonstrate a long-range surface plasmon resonance (LR-SPR) biosensor for the detection of whole cell by captured antigens A and B on the surface of red blood cells (RBCs) as a model. The LR-SPR sensor chip consists of high-refractive index glass, a Cytop film layer, and a thin gold (Au) film, which makes the evanescent field intensity and the penetration depth longer than con...

Length-Based Spawning Potential Ratio (LB-SPR) model was applied to describe the status of Javelin grunter, Pomadasys kaakan in the Persian Gulf and Oman Sea. From April 2002 to March 2019. 45,489 specimens were collected from fish landing sites monthly, and their length (FL) and weight were measured. The results of the present study showed that different gears captured most of the P. kaakan be...

Manipulation of dispersion curve for enhancing surface plasmon resonance (SPR) detection is proposed. Based on strong correlation between slope of dispersion curve and SPR angle shift, it is confirmed that dispersion curve characteristics can be employed as an analysis tool to evaluate SPR sensor performance and to predict anomalous plasmonic behaviors. Complicated resonance shift in SPR angle,...

The computer modeling is carried out for parameter of sensitivity of optoelectronic chemical and biosensors, using phenomena of surface plasmon resonance (SPR). The physical model of SPR-sensor’s is described with (or without) of modifications of sensitive gold film surface by a dielectric layer. The variants of increasing of sensitivity for SPR-biosensors, constructed on the principle gold – d...

In this paper, we propose a stochastic representation of a sung melodic contour, called stochastic phase representation (SPR), which can characterize both musical-note information and the dynamics of singing behaviors included in the melodic contour. The SPR is constructed by fitting probability distribution functions to F0 trajectories in the F0-∆F0 phase plane. Since fluctuations in singing c...

We prove that, for low-order (n ≤ 4) stable polynomial segments or interval polynomials, there always exists a fixed polynomial such that their ratio is SPR-invariant, thereby providing a rigorous proof of Anderson’s claim on SPR synthesis for the fourth-order stable interval polynomials. Moreover, the relationship between SPR synthesis for low-order polynomial segments and SPR synthesis for lo...

Taking advantage of the high impermeability property of graphene and the sharp surface plasmon resonance (SPR) curve of silver, we numerically demonstrate that SPR imaging biosensors with a graphene-on-silver substrate can be used to achieve the dramatically high sensitivity as well as to prevent silver oxidation. Results of our numerical study show that a silver substrate with a few graphene l...

The effect (Stark effect) of an applied electric field on the electronic states of molecular adsorbates was studied by measuring surface plasmon resonance (SPR) as a function of the wavelength of the incident light that excites the SPR. Using the Kramers-Kronig relation, Stark spectra comparable to those obtained with conventional methods were extracted from the electric field-induced SPR angul...

Sepiapterin reductase (SPR) catalyzes the last step in the pathway of tetrahydrobiopterin biosynthesis in tissues. SPR is phosphorylated by Ca2+-dependent protein kinases, which indicates that Ca2+-activated protein kinases may play a role in the regulation of SPR in vivo. Phosphorylation sites of rat sepiapterin reductase (rSPR) by Ca2+/calmodulin-dependent protein kinase II were determined in...