UNLABELLED Spray-dried monoclonal antibody (mAb) powders may offer applications more versatile than the freeze-dried cake, including preparing high-concentration formulations for subcutaneous administration. Published studies on this topic, however, are generally scarce. This study evaluates a pilot-scale spray dryer against a laboratory-scale dryer to spray-dry multiple mAbs in consideration o...

TiISiC, MMC monotapes have been successfully fabricated by vacuum plasma spraying. The as-sprayed MMC monotapes have a uniform fibre distribution, dense matrix and no fibre-matrix interfacial reaction. The effects of processing parameters such as H, flow rate, plasma current, chamber pressure and spray distance on the monotape temperature, porosity and fibre infiltration have been evaluated qua...

prove the dissolution property and oral bioavailability of poorly water-soluble drugs, solid dispersion methods have been extensively used and numerous approaches have been reported such as fusion, solvent evaporation, and spray-drying methods. However, these methods involve various problems. Solid dispersions prepared by fusion usually have the shortcoming of being tacky and unstable, and solv...

OBJECTIVES To quantify the temperature increments in a simulated dental pulp following irradiation with an Er:YAG laser, and to compare those increments when the laser is applied with and without water spray. METHODS Two cavities were prepared on either the buccal or lingual aspect of sound extracted teeth using the laser. One cavity was prepared with water spray, the other without and the or...

A droplet vaporization model has been developed for use in high pressure spray modeling. The model is a modification of the common Spalding vaporization model that accounts for the effects of high pressure on phase equilibrium, transport properties, and surface tension. The new model allows for a nonuniform temperature within the liquid by using a simple 2-zone model for the droplet. The effect...

Recently, the demand for concentrates and dry powders from natural fruit berry raw materials has been growing in food industry. Spray drying is a method that widely used to increase shelf life of products. However, obtaining clarified, unclarified juices, as well juices with pulp, by spraying certain difficulties. This due fact apple purees contain complex organic acids (malic, citric, etc.) co...

In recent years, there has been growing interest to use computational fluid dynamics (CFD) for exploring dropletparticles interaction under the turbulent flow of air inside spray dryer systems. The final goal is to predict the dried solid particle size and mass flux distributions under the conditions of collision, coalescence and agglomeration of the droplets and particles. The coarse-grained s...