we report three cases of asymptomatic celiac disease identified in children with down syndrome after being screened at around twenty-four months of age.  these cases raise the question as to what age is screening for celiac disease indicated in a child with down syndrome and no symptoms.

CARMEL, R. & HERBERT, V. (1967) Correctable intestinal defect of vitamin B12 absoprtion in pernicious anaemia. Annals of Internal Medicine, 67, 1201. COOKE, W.T., FONE, D.J., Cox, E.V., MEYNELL, M.J. & GADDIE, R. (1963) Acute folic acid deficiency of unknown aetiology: temperate sprue. Gut, 4, 292. CREAMER, B., SHORTER, R.G. & BAMFORTH, J. (1961) The turnover and shedding of epithelial cells. G...

Sprue-like enteropathy associated with olmesartan medoxomil use has been recently reported. Its clinical manifestations include diarrhea, weight loss and malabsorption. Duodenal biopsies show villous atrophy (VA) with or without intraepithelial lymphocytosis and inflammation of the lamina propria. Serology for celiac disease (CD) is negative and gluten-free diet does not result in clinical impr...

INTRODUCTION The term ‘malabsorption syndrome’ is non-specific and would seem to include diseases in which some abnormality of absorption exists. Though they may be of varied aetiology, most of them resemble each other and exhibit protein, carbohydrate, fat, minerals and vitamins deficiency. The clinical manifestations are similar to the disease known as `Sprue’ that is why the term malabsorpti...

Cases of sprue-like enteropathy associated with olmesartan have sporadically been encountered since it was first reported in 2012, and their most characteristic manifestation is severe diarrhea. We herein report the first case of sprue-like enteropathy manifesting as Wernicke-Korsakoff syndrome due to vitamin B1 malabsorption with only minimally increased bowel movements. When patients are rece...

Symptomatic disease from Strongyloides stercoralis has been recognized for the first time in Trinidad. Five cases are reported, all showing clinical features suggestive of a sprue-like syndrome. Subtotal jejunal villous atrophy was seen in one case and partial villous atrophy in two. Three patients had laparotomies because of suspected partial intestinal obstruction. A sprue-like syndrome in ce...

Collagenous sprue (CS) is a distinct clinicopathological disorder histologically defined by a thickened subepithelial band (Freeman, 2011). It is a rare condition which has been recently observed in a significant proportion of sprue-like enteropathy associated with olmesartan, a novel entity described by Rubio-Tapia et al. in 2012. CS is historically associated with a poor prognosis (Marthey et...