BACKGROUND Imepitoin was tested as a combination treatment with phenobarbital in an open-label mono-centre cohort study in dogs with drug-resistant epilepsy. Diagnosis of idiopathic epilepsy was based on clinical findings, magnetic resonance imaging and cerebrospinal fluid analysis. Three cohorts were treated. In cohort A, dogs not responding to phenobarbital with or without established add-on ...

OBJECTIVES To investigate the actual time of onset of osteonecrosis (ON) after high dose corticosteroid treatment in systemic lupus erythematosus (SLE). METHODS 72 patients with active SLE, who received high dose corticosteroid for the first time, for the development of ON at hips and knees were monitored by magnetic resonance imaging for at least 12 months. RESULTS ON lesions were detected...

BACKGROUND Asthma guidelines vary in their recommendations for the initial dose of inhaled corticosteroid (ICS) in asthma. A systematic review of the literature was conducted to establish the optimal starting dose of ICS for asthma in adults. METHODS Randomised controlled trials comparing two doses of the same ICS in adults with asthma and no concomitant inhaled or oral corticosteroid were as...

Introduction: Esophageal cancer is one of the most frequently occurring cancers in Iran and having a  high  incidence  rate  among  other  countries.  Radiotherapy  is  one  of  the  three  methods  (surgery,  radiotherapy and chemotherapy) for radical or palliative treatment of esophageal cancer. In this method  of treatment, the organs such as heart and spinal cord are regarded as organs at r...

INTRODUCTION Usage patterns and effectiveness of a longer-acting formulation of insulin glargine at a strength of 300 units per milliliter (Gla-300) have not been studied in real-world clinical practice. This study evaluated differences in dosing and clinical outcomes before and after Gla-300 treatment initiation in patients with type 2 diabetes starting or switching to treatment with Gla-300 t...

introduction: the selection of suitable beam angles and weights in external-beam radiotherapy is at present generally based upon the experience of the planner. therefore, automated selection of beam angles and weights in forward-planned radiotherapy will be beneficial. material and methods: in this work, an efficient method is presented within the matlab environment to investigate how to improv...

The concept of hormesis, or low-dose U-shaped responses, is now well established in toxicology and pharmacology but requires development in medicine and therapeutics. In doing so, care must be taken to not confuse metaphorical and chemical uses of the term hormesis. Low dose, continuous adaptive responses are fundamentally different than conventional pharmacology, and they may improve the scien...