is an important human fungal pathogen, in terms of both its Candida albicans clinical significance and its use as an experimental model for scientific investigation. Although this opportunistic pathogen is a natural component of the human flora, it can cause life-threatening infections in immunosuppressed patients. There are currently a limited number of antifungal molecules and drug targets, a...

in the present work, the bioassay screening of the essential oil and various extracts of two plants including fruits of heracleum persicum desf. and rhizomes of zingiber officinale rosc. have been studied with brine shrimp test. there is only one report about cytotoxicity of h. sphondylium in literature and so h. persicum has been used as second selection. at first essentials oil and various ex...

spirulina platensis, a cyanobacterium of economic important was studied for the tolerance to cadmium. the bioassay studies showed the ec50 value to be 1.53 mg/g. the cyanobacterium was very sensitive to low metal concentration and the productivity was also reduced. the chlorophyll pigments reduced with decreasing the algal biomass. the algal survival rate showed a marked reduction in their surv...

An improved bioassay for fluconazole was developed. This assay is sensitive in the clinically relevant range (2 to 40 micrograms/ml) and analyzes plasma, serum, and cerebrospinal fluid specimens; bioassay results correlate with results obtained by high-pressure liquid chromatography (HPLC). Bioassay and HPLC analyses of spiked plasma, serum, and cerebrospinal fluid samples (run as unknowns) gav...

In the present study it was aimed to determine acute toxicity of zinc on southern medicinal leech Hirudo verbana Carena, 1820 that being used in ecotoxicological studies. The experiment conducted for 96 hours using semi-static bioassay method with replicate two times. leeches were exposed concentrations 6.25 mg/L, 12.50 25 50 100 mg/L and 200 respectively. As a result experiment, LC50 values 24...

Experiments were designed in a bioassay system to analyze the effect of elevated (from 5.9 mM to 7.5-45.9 mM) extracellular K+ concentration on the release of endothelium-derived relaxing factor. Segments of canine femoral artery with endothelium (donor segment) were mounted in an organ bath and perfused with modified Krebs-Ringer bicarbonate solution; the effluent from the donor segment was us...

An agar well diffusion bioassay method for determination of clarithromycin in human plasma, using Micrococcus Luteus ATCC 9341 as the assay organism, was compared with a selective high-performance liquid chromatographic (HPLC) method with UV detection. Spiked plasma was used to prepare standard and control samples for both methods. The results of the bioassay analyses with spiked plasma samples...

An agar well diffusion bioassay method for determination of clarithromycin in human plasma, using Micrococcus Luteus ATCC 9341 as the assay organism, was compared with a selective high-performance liquid chromatographic (HPLC) method with UV detection. Spiked plasma was used to prepare standard and control samples for both methods. The results of the bioassay analyses with spiked plasma samples...

The standard procedure for definitive detection of BoNT-producing Clostridia is a culture method combined with neurotoxin detection using a standard mouse bioassay (MBA). The mouse bioassay is highly sensitive and specific, but it is expensive and time-consuming, and there are ethical concerns due to use of laboratory animals. Cell-based assays provide an alternative to the MBA in screening for...