BACKGROUND Although the benefits of statins accrue over time, treatment discontinuation is common. Examining the patterns of statin discontinuation, reinitiation, and persistence after reinitiation among Medicare beneficiaries after hospital discharge for a myocardial infarction may help increase statin use in high-risk patients. METHODS AND RESULTS Medicare beneficiaries with a statin fill c...

Statin medications are recommended for patients who have not achieved low-density lipoprotein cholesterol (LDL-C) goals through lifestyle modifications. The objective of this retrospective observational study was to examine statin medication usage patterns and the relationship with LDL-C goal levels (according to Adult Treatment Panel III guidelines) among a cohort of employees of a major finan...

AIM To evaluate the presence of the so called "statin escape" phenomenon among hyperlipidemic subjects attending a lipid clinic. METHODS This was a retrospective analysis of 1240 hyperlipidemic individuals followed-up for ≥ 3 years. We excluded those individuals meeting one of the following criteria: Use of statin therapy at baseline visit, discontinuation of statin treatment at most recent v...

hdl can prevent ldl-c oxidation. the low hdl-c state also may benefit clinically from supplemented antioxidant. this study was designed to evaluate the combination therapy of statin and vitamin e in hypercholesterolemic patients. the patients were randomized in a clinical trial aimed to avaluate the effect of vitamin e and/or statin.the life style of patients didn't alter during intervention. t...

INTRODUCTION There is a multitude of evidence supporting the benefit of statin use in cardiovascular disease; however, statin-induced myopathy is a major reason for statin discontinuation and non-adherence. Vitamin D deficiency has been independently associated with muscle weakness and severe myopathy, and may be a confounder for statin-induced myopathies. Since there is no consensus on a treat...

3-hydroxy-3-methylglutaryl-coa reductase inhibitors (statins), are effective serum cholesterol-lowering agents which also have anti-inflammatory properties. the objective of this study was to evaluate the effect of atorvastatin on bronchial hyperresponsiveness. adult patients (age 14 to 65 years) with bronchial hyperresponsiveness (bhr) diagnosis based on the spirometry with methacholine challe...

objectives: cow urine ark (cua), known as “amrita” as mentioned in ayurveda, contains‎ anti-hyperglycemic and antioxidant effects. therefore, we designed the present study to evaluate the lipid ‎lowering activity of cua and its possible implication in metabolic syndrome.‎ materials and methods: thirty guinea pigs of either sex were divided into five groups: group 1 and 2 serving as a vehicle ‎a...

BACKGROUND Statin therapy is a proven effective treatment of hyperlipidemia. However, a significant number of patients cannot tolerate statins. This study was conducted to review treatment strategies for patients intolerant to statin therapy with a focus on intermittent statin dosing. METHODS AND RESULTS We performed a retrospective analysis of medical records of 1,605 patients referred to th...

BACKGROUND Systematic data on discontinuation of statins in routine practice of medicine are limited. OBJECTIVE To investigate the reasons for statin discontinuation and the role of statin-related events (clinical events or symptoms believed to have been caused by statins) in routine care settings. DESIGN A retrospective cohort study. SETTING Practices affiliated with Brigham and Women's ...

This article from the National Lipid Association Statin Intolerance Panel provides a framework for understanding statin intolerance and makes general recommendations for health professionals. For specific guidance on adverse events related to muscle, liver, cognition, and glucose metabolism, one should refer to the other reports of the Statin Safety Task Force for those topics. Although statin ...