BACKGROUND We have previously found that Wnt signaling is activated in mesothelioma cells. To clarify the effect of blocking Wnt signaling in mesothelioma, the expression of dishevelled (Dvl), an intermediator of Wnt signaling, was down-regulated by a reformed type of small interfering RNA (siRNA), stealth RNAi, which can reduce the cytotoxic interferon response unlike conventional siRNA. MAT...

Article history: Received 13 August 2012 Received in revised form 31 December 2013 Accepted 16 January 2014 Available online 23 January 2014 Companies can increase executive compensation by allowing dividends to be paid on unvested restricted stocks grants, also known as stealth compensation. Examining all S&P 500 firms over the period 2003–2007, we find that more than half of the dividend payi...

Stealth assessment represents a promising way to address the needs of validly measuring and supporting important 21st century competencies (e.g., creativity, problem solving) within interactive digital environments (e.g., video games). The assessment is woven into the environment such that it becomes invisible to students, which is conducive to eliciting targeted competencies (Shute, 2011). Ste...

Whilst large organisations need foresight, they are also notorious in their bias for short term thinking, sometimes rejecting or even suppressing foresight. This paper describes a variety of 'stealth' techniques to embed foresight methods and models within mainstream business and strategy-development processes as a means to support internal innovation and summarises experience gained in applyin...

This article examines the key concepts of active learning, metacognition, and transfer of knowledge, as put forth by the National Research Council’s approach to the new science of learning, in relation to ways that E-Learning applications might improve learning both inside and outside the classroom. Several initiatives are highlighted to illustrate innovative ways to improve E-Learning by linki...

Same as Report (SAR) 18. NUMBER

We examined the therapeutic activity of betamethasone disodium 21-phosphate (BP) encapsulated in biocompatible and biodegradable blended nanoparticles of poly (D,L-lactic/glycolic acid) (PLGA)/poly(D,L-lactic acid) (PLA) homopolymers and polyethylene glycol (PEG)-block-PLGA/PLA copolymers (stealth nanosteroid) in experimental arthritis models. Various stealth nanosteroids with a size of 45 to 1...

Erlotinib (ELT) as a small molecule with poor solubility, poor bioavailability, and instability in gastrointestinal environment, has been considered as a therapeutic agent for Non-Small-Cell Lung Cancer (NSCLC) therapy through oral administration. In the present study, ELT-liposome and ELT-NLCs were successfully prepared and characterized by assessment of the particle size, zeta potential (ZP),...

Stealth liposomes can be used to extend the blood circulation time of encapsulated therapeutics. Inclusion of 2 molar % porphyrin-phospholipid (PoP) imparted optimal near infrared (NIR) light-triggered release of doxorubicin (Dox) from conventional sterically stabilized stealth liposomes. The type and amount of PoP affected drug loading, serum stability and drug release induced by NIR light. Ch...

PURPOSE The therapeutic effects of betamethasone phosphate (BP) encapsulated in biocompatible and biodegradable blended nanoparticles of poly(lactic acid) (PLA) homopolymers and PEG-block-PLA copolymers (stealth nanosteroids) were examined in an experimental autoimmune uveoretinitis (EAU) model in Lewis rats. METHODS EAU was induced by S-antigen peptide in Lewis rats. Accumulation of systemic...