tissue and cell transplantation are regarded as a popular procedure in clinical sciences, prospecting a new horizon for several incurable diseases. along with its usefulness, many ethical concerns accompany this development. the ethical issue of organ transplant is unique to the source used which includes: living related, living unrelated, cadaveric, and xenotransplant. obtaining organs has a s...

objective(s): bone marrow-derived mesenchymal stem cells (bm-mscs) potentials make them appropriate for cell therapy including ability of differentiation and release of anti-inflammatory cytokines and growth factors secreta. for treatment of azoospermia to induce proliferation and differentiation of germ cells, mscs transplantation has been introduced. the aim of the present experimental case-c...

the provision of an adequate quantity of cells with proper function and purity is one of the main challenges of tissue engineering studies. stem cells, with their self-renewal and differentiation capacity, are considered one of the main cell sources in the field of tissue engineering. previously, the use of chemical factors seemed to be the only possible way for stem cell differentiation. howev...

objective: demyelination of cns axons occurs under pathological conditions such as multiple sclerosis and spinal cord injuries, but can be repaired by cell therapy. within the cns remyelination can be achieved by transplantation of neural stem cells (nscs). nscs are self-renewing cells that maintain the capacity to differentiate into cns-specific cell types and can differentiate into the three ...

cancer stem cells (csc) are the tumor-associated cells existed within tumors or hematological cancers which share characteristics similar to normal stem cells. the common characteristics of a normal stem cell and a csc are their differentiation capacity and self-renewal in tumors. the expression pattern of csc markers differs depending on the type and location of cancers. cd molecules are proba...

objective(s):some evidence showed that calcitriol has an important role in regulating growth and differentiation of mesenchymal stem cells (mscs). however, the interaction between mesenchymal stem cells and macrophage is not clear yet.  the current study was done to investigate the in vitro effects of calcitriol on the interactions between bone marrow-derived mscs and rat macrophages. materials...

introduction : in iran along with other countries, as transplant technology progresses and advances, the number of patients undergoing transplantation is rising steadily. in order to make stem-cell transplantation (sct) safer and more effective, psychological distress of patients must be taken in to account. patients are facing challenges pre- and post-transplantation. this study attempts to me...

background: thalassemia is probably the most common single gene disorder causing a major public health problem in the world. currently, allogenic hematopoietic stem cell transplantation (hsct) is the only curative therapy for thalassemia. one major limitation of hsct is the lack of hla-identical sibling donors, so attention has turned to finding phenotypically matched unrelated donors. patients...

the stem cells can be considered as the miracle of creation, because, they are a major reservoir of the bioactive factors, molecules and cells. these reservoir cells play a major role in development and growth of the tissues and organs. regardless of the differences in differentiation capacity of embryonic and adult stem cells, both the cells are rich sources of stem cells with therapeutic appl...

in cell therapy and regenerative medicine, a reliable source of stem cells together with cytokine growth factors and biomaterial scaffolds seem necessary. as adipose tissue is easy accessible and is abundant source of adult stem cells and can differentiate along multiple lineages, it can be considered as a good candidate in aesthetic medicine. the clinical application of adipose-derived stem ce...