We propose a nonparametric Bayes-based clustering algorithm to detect associations with rare and common single-nucleotide polymorphisms (SNPs) for quantitative traits. Unlike current methods, our approach identifies associations with rare genetic variants at the variant level, not the gene level. In this method, we use a Dirichlet process prior for the distribution of SNP-specific regression co...

BACKGROUND Concerns about falling, a construct related to fear of falling, is increased in people with Parkinson's disease (PD) and is recognized as a barrier for exercise, negatively affecting health-related quality of life and participation. AIM To investigate modifiable factors associated with concerns about falling in elderly with mild-to-moderate PD. METHODS Eighty-nine elderly (39 fem...

We examined the effects of objectively measured physical activity (PA) and physical fitness (PF) on fear of falling (FOF) among older adults. The subjects were 94 Korean females aged 65-79. PA was measured with accelerometers, PF with the senior fitness test and FOF with the Korean Survey of Activities and Fear of Falling in the Elderly. With the subjects' age, number of chronic conditions, and...

Our aim was to explore the association of physical performance and pain with fear of falling among community-dwelling Japanese women.The subjects were 278 women aged 65 years and over. We collected information on fear of falling, painful joints, comorbidities, falls in the previous year, and cataracts. Walking time (distance of 6 m), chair stand time (5 times), grip strength, the timed up and g...

Abstract In this paper interparticle potential model of the lattice Boltzmann method (LBM) is used to simulate deformation and breakup of a falling droplet under gravity force. First this model is applied to ensure that the surface tension effect is properly implemented in this model. Two tests have been considered. First, it has been checked an initial square drop in a 2D domain can freely def...

BACKGROUND Falls are a major factor contributing to fragility fractures. Patients with lumbar spinal stenosis have an increased risk of falling. We are aware of no prior report demonstrating the effect of medical treatment and decompression surgery on the risk of patients with lumbar spinal stenosis falling. METHODS From June to November 2011, seventy-six patients were enrolled into the surge...

motor vehicle and falling down are responsible for the most number of traumatic injuries. this study aimed to compare the characteristics of traumatic brain injury among accident and falling down cases. in this analytical cross- sectional study, data were collected from the records of cadavers who died due to accident or falling down and referred to kahrizak dissection hall, tehran forensic med...