Strengthening of cell-matrix adhesions in response to applied force has been well documented. However, while implied by various lines of evidence, the force-mediated strengthening of cell-cell adhesions has not been directly demonstrated. In the current study, we present results consistent with force strengthening in adherens junctions, obtained by application of different force profiles to VE-...

Co-clusters in ternary or higher order metallic alloys are metastable structures involving two or more distinct alloying atoms that retain the structure of the host lattice. A thermodynamic model based on a single interaction energy of dissimilar nearest neighbour interaction energy is presented, and a model for the strengthening due to these co-cluster dimers is derived. The model includes a n...

This study examined the effects of prosodic boundary and prominence on English /sCV/ sequences. One important finding was that the domain-initial strengthening effect was not strictly confined to the first segment, but it could extend over the entire /sCV/ sequence, although it was further modulated by prominence. Another important finding was shortening of VOT for the voiceless stop in /sCV/ u...

A physically-based numerical model is developed to predict the microstructural evolution and strengthening in Al-Cu-Mg alloys during isothermal treatments. The modelling of the formation kinetics of the precipitates is based on the Kampmann and Wagner model. The strengthening by the shearable Cu:Mg co-clusters is modelled on the basis of modulus strengthening mechanism and the strengthening by ...