Streptozotocin (STZ) is believed to induce pancreatic beta cell death in mice by depleting the cell of NAD+NADH. The drug is known to cause a greater depletion of beta cell NAD+NADH in C57bl/6J mice than in Balb/c mice. To investigate the basis for this strain difference, we compared the effects of streptozotocin on poly(ADP-ribose)polymerase (PARP) activation - the major site of NAD consumptio...

BACKGROUND Black cumin (Nigella sativa) is an ancient herbal medicine recommended by the World Health Organization. The antioxidant and antihyperglycemic effects of black cumin are well established. Amelioration of renal dysfunction in nephrotoxic rats with black cumin treatment has also been noted. However, the effect of black cumin treatment on renal dysfunction in diabetes mellitus has not b...

Background: Diabetes mellitus is one of the main causes death due to complications that involve many organs such as heart, kidney, retina and others. Mesenchymal stem cell (MSC) has been demonstrated be effective in treatment diabetes. Aim work: To evaluate effect cells diabetic cardiomyopathy clarifying their role oxidative stress inflammation. Material methods: 30 adult male albino rats were ...

Marchand KC, Arany EJ, Hill DJ. Effects of atorvastatin on the regeneration of pancreatic -cells after streptozotocin treatment in the neonatal rodent. Am J Physiol Endocrinol Metab 299: E92–E100, 2010. First published April 13, 2010; doi:10.1152/ajpendo.00132.2010.—To investigate the role of statins in -cell regeneration a model of streptozotocin (STZ)-induced -cell injury was used in the neon...

Diabetic retinopathy (DR) is the leading cause of blindness among the American working population. The purpose of this study is to establish a new diabetic animal model using a cone-dominant avian species to address the distorted color vision and altered cone pathway responses in prediabetic and early diabetic patients. Chicken embryos were injected with either streptozotocin (STZ), high concen...

Diabetes is a metabolic disorder characterized by hyperglycemia resulting from either the deficiency in insulin secretion or action of can affect numerous different organ systems body and, over time, lead to serious complications. Complications are microvascular macrovascular. To evaluate anti-diabetic effect Phyllanthus niruri silver nano-particles. Streptozotocin (STZ) 50mg/kg used induce dia...

Ghrelin, an orexigenic peptide produced in the stomach, is increased in streptozotocin (STZ)-induced diabetic (DM) mice. This study clarifies the regulation of ghrelin levels by leptin in STZ-DM mice. STZ-DM mice had higher plasma ghrelin concentrations and greater ghrelin mRNA expression than control mice. Changes in ghrelin levels were dose dependently attenuated by the subcutaneous injection...

BACKGROUND Experimental models are developed for the purpose of enhancing the understanding of the pathophysiological mechanisms involved in diabetes. Experimental findings lead to the development of treatment strategies to maintain metabolic conditions as close to normal as possible. There are several reports about streptozotocin induced mild diabetes to reproduce type 2 diabetes. However, stu...

AIMS/INTRODUCTION Sphingosine-1-phosphate (S1P), a multifunctional bioactive lipid mediator, is involved in various diseases. Apolipoprotein M (ApoM) carries S1P on high-density lipoprotein and modulates S1P metabolism to increase the total S1P mass in the body. Both S1P and ApoM are involved in diabetes. MATERIALS AND METHODS The present study examined the modulation of S1P and ApoM levels i...

Abstract Objective This study was aimed at determining the nephroprotective potential of Sphaeranthus indicus Linn methanol extract (SME) against hyperglycemia and dyslipidemia in streptozotocin (STZ)-induced diabetic nephropathy (DNP) adult Wistar albino rats. Materials Methods Following STZ-induced diabetes, rats either sex with serum glucose level more than 250 mg/dL were chosen randomized i...