ackground: In September 2003, North America’s first supervised injection facility (SIF) opened in Vancouver, Canada. We sought to examine he incidence and characteristics of overdose events at the SIF. ethods: The Vancouver SIF evaluation involves a comprehensive database within the SIF and the Scientific Evaluation of Supervised njection (SEOSI) cohort consisting of 1046 SIF users. We examined...

BACKGROUND In recent years, there has been increased interest in supervised safer injecting facilities (SIF) as a strategy to reduce the harms of illicit drug use; however, little work has been done to assess drug users' satisfaction with this service. This study was undertaken to explore injection drug users' experiences and opinions regarding North America's first SIF in Vancouver, Canada. ...

Passive remote sensing (RS) of solar-induced chlorophyll fluorescence (SIF) of vegetation is feasible at ground level, airborne level and space borne level with certain prototypes. Fraunhofer Line Discrimination (FLD) and its improved methods have been widely used to extract SIF. Unlike processing at ground level, these methods do not work so well since it is not easy to obtain the solar incide...

Nuclear bodies (NBs) are structures that concentrate proteins, RNAs, and ribonucleoproteins that perform functions essential to gene expression. How NBs assemble is not well understood. We studied the Drosophila histone locus body (HLB), a NB that concentrates factors required for histone mRNA biosynthesis at the replication-dependent histone gene locus. We coupled biochemical analysis with con...

In a mutant strain of Hydractinia (Cnidaria: Hydrozoa), the polyps develop ectopic supernumerary tentacles and heads (hypostomes) after an initial phase of wild-type growth. In order to elucidate the molecular mechanisms implicated in the development of aberrant phenotypes, we tried to enhance or suppress the expressivity of this hypomorphic mutation by exposing subclones to factors supposedly ...

In this study, we evaluated chlorophyll fluorescence (CF) under two extreme 13 illumination conditions at plant scale with a passive spectroradiometer. Fluorescence (F) was 14 estimated by reading directly from radiance spectra of a variety of plants illuminated with 15 light-emitting diode (LED) grow lights in the laboratory. Solar-induced fluorescence (SIF) was 16 estimated from spectral meas...

INTRODUCTION Correct choice of osteosynthesis method is a very important factor in providing the optimal conditions for appropriate healing of the fracture. There are still disagreements about the method of stabilization of some long bone fractures. Critically observed, no method of fracture fixation is ideal. Each osteosynthesis method has both advantages and weaknesses. OBJECTIVE The object...

Intracellular Salmonella enterica induce a massive remodeling of the endosomal system in infected host cells. One dramatic consequence of this interference is the induction of various extensive tubular aggregations of membrane vesicles, and tubules positive for late endosomal/lysosomal markers are referred to as Salmonella-induced filaments or SIF. SIF are highly dynamic in nature with extensio...

Salmonella enterica serovar Typhimurium has the fascinating ability to form tubular structures known as Salmonella-induced filaments (Sifs) in host cells. Here, we show that the prevalence of the Sif phenotype in HeLa cells is affected by host cell density, growth, and the multiplicity of infection. Sif formation was observed in cells that displayed rapid intracellular bacterial replication and...

The SCOPE (soil canopy observation of photochemistry and energy fluxes) model has been widely used to interpret solar-induced chlorophyll fluorescence (SIF) and investigate the SIF-photosynthesis links at different temporal and spatial scales in recent years. In the SCOPE model, the fluorescence quantum efficiency in dark-adapted conditions (FQE) for Photosystem II (fqe2) and Photosystem I (fqe...