Protein structural class describes the overall folding type of a protein or its domain. A number of methods were developed to predict protein structural class based on its primary sequence. The homology of the predicted sequences with respect to the training sequences is a key attribute for the prediction performance. In this article we investigated the FDOD method developed by Jin et al. [Jin,...

The prediction of 1D structural properties of proteins is an important step toward the prediction of protein structure and function, not only in the ab initio case but also when homology information to known structures is available. Despite this the vast majority of 1D predictors do not incorporate homology information into the prediction process. We develop a novel structural alignment method,...

DNA is found in the cell largely as a negatively supercoiled molecule. This high-energy form of the genetic material can engender sequence-dependent structures, such as cruciforms, Z-DNA, or H-DNA, even though they are not favored by conventional conditions in relaxed DNA. A key feature of DNA in living systems is the presence of homology. We have sought homology-dependent structural phenomena ...

In this article, we show the existence of certain exact sequences with respect to two homology theories, called d-homology and extended d-homology. We present sufficient conditions for the existence of long exact extended d- homology sequence. Also we give some illustrative examples.

The theory of intersection homology was developed to study the singularities of a topologically stratified space. This paper incorporates this theory into the already developed framework of persistent homology. We demonstrate that persistent intersection homology gives useful information about the relationship between an embedded stratified space and its singularities. We give, and prove the co...

in this article, we show the existence of certain exact sequences with respect to two homology theories, called d-homology and extended d-homology. we present sufficient conditions for the existence of long exact extended d- homology sequence. also we give some illustrative examples.

GPCR-ModSim (http://open.gpcr-modsim.org) is a centralized and easy to use service dedicated to the structural modeling of G-protein Coupled Receptors (GPCRs). 3D molecular models can be generated from amino acid sequence by homology-modeling techniques, considering different receptor conformations. GPCR-ModSim includes a membrane insertion and molecular dynamics (MD) equilibration protocol, wh...