Significance of early biochemical markers of atherosclerosis in subclinical hypothyroidism patients with normal lipid profile. a b c d Original article sHT Nitric oxide hs-CRP atherosclerosis TSH

Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with increased cardiovascular (CV) mortality. Toll-like receptor-4 (TLR4) activates the innate immune response via NF-kB pathway and mitogen-activated protein kinase signaling, leading to expression of proinflammatory cytokines and chemokines. The G allele of TLR4 rs4986790 (+896A>G, Asp299Gly) gene polymorphism has been imp...

BACKGROUND AND AIM We conducted a prospective study to investigate the possible relationship between the tortuosity of coronary arteries (TCA) and carotid intima-media thickness (CIMT), and also compare TCA to retinal artery tortuosity. METHODS One hundred and five participants with nonsignificant coronary plaque or normal coronary angiogram were included. To determine subclinical atheroscler...

INTRODUCTION Individuals with fatty liver (FL) have an increased risk of coronary artery disease (CAD) probably due to its association with cardiometabolic risk factors (CMRF). OBJECTIVE To know the prevalence of FL and analyze its association with CMRF and subclinical atherosclerosis, in a sample of Mexican Mestizo population. MATERIAL AND METHODS This study included 846 subjects from the ...

Estrogen Replacement Therapy Reduces the Progression of Subclinical Atherosclerosis in Healthy Postmenopausal Women Without Preexisting Cardiovascular Disease To the Editor: Two articles have appeared in Circulation1,2 that have cited the Estrogen in the Prevention of Atherosclerosis Trial (EPAT)3 as supportive evidence that hormone replacement therapy (HRT) has no benefit on atherosclerosis in...

BACKGROUND Non-diabetic chronic kidney disease (CKD) patients are a heterogeneous group with a variety of prognosis. We investigated the role of subclinical carotid atherosclerosis for the prediction of adverse cardiovascular (CV) outcomes in these patients, and tried to identify clinical and echocardiographic parameters associated with subclinical carotid atherosclerosis. METHODS As a prospe...

INTRODUCTION Advanced glycation endproducts (AGEs) may be involved in the development of atherosclerosis, beyond diabetes and renal disease. Skin autofluorescence (AF) is a non-invasive marker for AGEs. We examined whether skin AF is increased in (subclinical) atherosclerosis and associated with the degree of atherosclerosis independent of diabetes and renal function. METHODS A cross-sectiona...

Aim. To detect the frequency of subclinical atherosclerosis in rheumatoid arthritis patients without clinically evident atherosclerosis and to correlate its presence with the disease activity. Patients and Methods. Our study includes 112 RA patients (group 1) and 40 healthy controls (group 11). All patients and controls were subjected to full history taking, clinical examination, and laboratory...

Abstract The relationship between intake of saturated fats and subclinical atherosclerosis, as well the possible influence genetic variants, is poorly understood investigated. We aimed to investigate this relationship, with a hypothesis that it would be positive, explore whether genetics may modulate it, using data from European cohort including 3,407 participants aged 54–79 at high risk cardio...