Background: Pain and pruritus are two common symptoms in dermatology that are transmitted with unmyelinated C fibers via substance P. Topical capsaicin is effective due to depletion of never endings from substance P. Objective: The efficacy and side effects capsaicin gel in painful and pruritic skin disorders was compared to placebo. Patients and Methods: In a controlled clinical trial, 4...

A high content of substance P (124 ng/g wet tissue) was demonstrated by radioimmunoassay in lymph node metastases in a patient with bilateral ovarian carcinoid tumours. The plasma substance P level was elevated but urinary 5-hydroxyindoleacetic acid (5-HIAA) was low. It is suggested that, in some carcinoid patients, an elevated plasma substance P level may help diagnosis and follow-up when urin...

Communication between nerves and immune and inflammatory cells of the small and large intestine plays a major role in the modulation of several intestinal functions, including intestinal motility, ion transport, and mucosal permeability. Neuroimmune interactions at intestinal sites have been associated with the pathophysiology of infectious and enterotoxin-mediated diarrhea and intestinal infla...