Nonclinical assessment of drug abuse and dependence is the subject of several recent regulatory guidelines, which are generally aligned on the methods to be employed. The most direct approach to assessing reinforcing properties of a drug is the self-administration procedure whereby animals can initiate intravenous injections of the test substance, something they readily do with prototypic drugs...

Nonclinical assessment of drug abuse and dependence is the subject of several recent regulatory guidelines, which are generally aligned on the methods to be employed. The most direct approach to assessing reinforcing properties of a drug is the self-administration procedure whereby animals can initiate intravenous injections of the test substance, something they readily do with prototypic drugs...

Complex patterns of multiple substance use pose clinical and methodological challenges for substance abuse clinical trials research. To increase measurement precision and internal validity, the modal approach has been to target both treatment interventions and outcome assessment to a single class of abused substance. This strategy warrants reconsideration because it entails limitations in recru...

The research is aimed at identifying the specifics of components emotional intelligence (EQ) in persons with different experiences substance abuse. study involved 157 respondents aged 35 to 45 years, whom 111 were dependent on psychoactive substances and 46 never used them. empirical was carried out using Emotional Intelligence Questionnaire (EmIn) by D.V. Lyusin, Balanced Empathy Scale (BEES) ...

Background: This study investigated the correlation between risk-taking and relapse among methamphetamine (MA) abusers undergoing the Matrix Model of treatment. Methods: This cross-sectional study was conducted on male patients who were stimulant drug abusers undergoing the matrix treatment in the National Center for Addiction Research. A sampling was done using the availability method includin...

Background: Drug abuse is a severe and chronic disorder that leaves morbidity, disability and premature mortality in the society. The study of death due to substance abuse provides useful information for local, national and international administrators. Thus, by identifying the factors that have an impact on overdose-related mortality we can provide suitable intervention for vulnerable groups. ...

OBJECTIVE To examine family physicians' career prevalence and monthly incidence of workplace abuse by controlled substance prescription seekers. DESIGN A 4-page cross-sectional survey. SETTING A family medicine continuing medical education event in Halifax, NS. PARTICIPANTS The survey was distributed to 316 family physicians attending the continuing medical education event. MAIN OUTCOME...

Inhalants are a group of substances that have mind-altering or psychoactive effects when inhaled. The intoxicating effect makes them liable to abuse. Volatility is the common physical characteristic shared by all inhalants. Inhalant abuse is a worldwide problem. The substances abused are numerous, cheap, legal and easily available (Table 1). They are usually emptied into a plastic bag or a used...

This paper describes the application of Raman spectroscopy to the detection of exogenous substances in cyanoacrylate-fumed fingerprints. The scenario considered was that of an individual handling a substance and subsequently depositing a contaminated fingerprint. These fingerprints were enhanced by cyanoacrylate fuming, a process in which a layer of white cyanoacrylate polymer is deposited on t...

Preclinical assessment of drug abuse and dependence has been the subject of several recent regulatory guidelines. Both the European and US authorities recommend a tiered approach and are generally aligned on the methods which should be used. The first tier simply compares the pharmacology of the novel substance to known drugs of abuse. The second tier aims to identify abuse and dependence liabi...