نتایج جستجو برای: substrate inhibition

تعداد نتایج: 456722  

Journal: :FEBS letters 1997
H Berry H Debat V Larreta-Garde

Soybean lipoxygenase-1 kinetics are known to show product and substrate inhibition. With linoleic acid as the substrate and using a simple Michaelis-Menten formulation, we have shown that K(ss), the substrate inhibition constant was increased by more than five-fold when initial oxygen concentration was increased from 228 to 1140 microM. Excess substrate inhibition is in fact almost avoided at h...

2004
F. C. Corazza L. P. V. Calsavara F. F. Moraes G. M. Zanin I. Neitzel

Neural networks and hybrid models were used to study substrate and product inhibition observed in the enzymatic hydrolysis of cellobiose at 40oC, 50oC and 55oC, pH 4.8, using cellobiose solutions with or without the addition of exogenous glucose. Firstly, the initial velocity method and nonlinear fitting with Statistica were used to determine the kinetic parameters for either the uncompetitive ...

Journal: :Biochimica et Biophysica Acta (BBA) - Bioenergetics 2014

Journal: :The EMBO journal 2006
Jacques-Philippe Colletier Didier Fournier Harry M Greenblatt Jure Stojan Joel L Sussman Giuseppe Zaccai Israel Silman Martin Weik

Acetylcholinesterase (AChE) terminates nerve-impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter, acetylcholine. Substrate traffic in AChE involves at least two binding sites, the catalytic and peripheral anionic sites, which have been suggested to be allosterically related and involved in substrate inhibition. Here, we present the crystal structures of Torp...

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