BACKGROUND The authors examined the notion that a reduction in succinylcholine dose from 1 mg/kg to approximately 0.6 mg/kg would allow a faster recovery of spontaneous ventilation and reduction in the incidence of hemoglobin desaturation during the period of apnea in simulated complete upper airway obstruction situations. METHODS This prospective, randomized, double-blind study involved 60 p...

To the Editor:—Schreiber et al. noted an association between larger doses of succinylcholine and a reduced incidence of fasciculation and myalgia. However, pretreatment with a nondepolarizing neuromuscular blocker is also associated with a reduced risk of fasciculation and myalgia. It is a common practice for clinicians to use a larger dose of succinylcholine when they have provided pretreatmen...

To the Editor:—Schreiber et al. noted an association between larger doses of succinylcholine and a reduced incidence of fasciculation and myalgia. However, pretreatment with a nondepolarizing neuromuscular blocker is also associated with a reduced risk of fasciculation and myalgia. It is a common practice for clinicians to use a larger dose of succinylcholine when they have provided pretreatmen...

Intraocular pressure changes following modified ECT with and without succinylcholine were studied in Sixty cases. The pressure rose in both the conditions though the rise was more marked and longer lasting when succinylcholine was used.

Background: Providing better surgical conditions with meticulous control of Intraocular Pressure (IOP) is one of the most important factors that affect the success rate in ophthalmic surgery. Clonidine is a selective central α2 agonist with analgesic, antianxiety and sedative effects which makes it a good choice in premedication recently. In this study, we compared the effects of oral clonidine...

The decrease of “functional” endplate receptors in MG can decrease the response to the chemical transmitter acetylcholine, as well as to the depolarizing muscle relaxant succinylcholine. In contrast, the decreased “safety margin” results in a marked sensitivity to nondepolarising relaxants. In normal patients, the wide “safety margin” may explain the slow onset of nondepolarizing block, as well...

To the Editor-The appropriate review, "Anesthesia for Major Thermal Injury," overstates the contraindication to succinylcholine on pages 754 (". . . succinylcholine . . . >24 h after burn injury is unsafe") and 755 (". . . safe only within 24 h of a burn").' The safe period for burn patients is 6-7 days after a burn injury, whereas that for denervation is 4 days. Studies beginning 6 days after ...

To the Editor:—Schreiber et al. noted an association between larger doses of succinylcholine and a reduced incidence of fasciculation and myalgia. However, pretreatment with a nondepolarizing neuromuscular blocker is also associated with a reduced risk of fasciculation and myalgia. It is a common practice for clinicians to use a larger dose of succinylcholine when they have provided pretreatmen...

Fifteen patients demonstrating unexpected prolonged apnoea lasting several hours after succinylcholine have been treated by a new preparation of human serum cholinesterase. Adequate spontaneous respiration was re-established in an average period of ten minutes after the injection. In 12 patients biochemical genetic examinations confirmed the presence of an atypical serum cholinesterase. In thre...