Submit Manuscript | http://medcraveonline.com infectious diseases [1-7]. These drugs were the first efficient treatment to be employed systematically for the prevention and cure of bacterial infections [8-11]. One of the first sulfonamides identified by Domagk et al. [8,9] was the red azo dye known as Prontosil [8,9]. It was active against streptococcal infection in vivo. There have been many a...