OBJECTIVES To investigate whether acupuncture is superior to placebo and equivalent to sumatriptan for the early treatment of an acute migraine attack. DESIGN Randomized, partly double-blind (sumatriptan versus placebo) trial. SETTING Two hospitals in Germany (one specialized in traditional Chinese medicine and one in the treatment of headache). SUBJECTS A total of 179 migraineurs experie...

OBJECTIVES To investigate the efficacy of a second subcutaneous dose of 6 mg sumatriptan in the treatment of recurrence of headache after successful treatment of a migraine attack with an initial 6 mg dose. METHODS In a prospective, randomised, placebo controlled, double blind, parallel group study, 803 patients were treated for one to three migraine attacks with severe or moderate headache w...

lithium is a drug used for the treatment of bipolar disorder. it has several mechanisms of action, and recently it is shown that lithium can antagonize the 5-ht1b/1d serotonin receptors. sumatriptan is a 5-ht1b/1d receptor agonist used for the treatment of cluster headaches and migraine which might cause memory impairment as a potential side effect. in this study, effects of lithium on sumatrip...

Sumatriptan is a novel and highly effective drug against migraine and cluster headache attacks. The drug is known to exert its effect through the modulation of serotonin (5-HT)mediated neurotransmission. 5-HT1B receptors in rats and 5-HT1D receptors in humans have been thought to be likely targets of sumatriptan. In the present study the effect of varying dose and duration of sumatriptan on the...

BACKGROUND The 5-HT1 agonist sumatriptan, used in the treatment of migraine, can cause chest pain. AIM To investigate the effect of a therapeutic dose of sumatriptan (6 mg s.c.) on oesophageal motility. METHODS In 16 normal healthy subjects aged 19-32 years (9 males), the manometric response of the lower oesophageal sphincter (sleeve sensor), oesophageal body (four sites), stomach and phary...

Background: Sodium valproate (SV) has been approved for migraine prophylaxis and its intravenous form is used to treat acute migraine attacks. We compared the efficacy and safety of intravenous SV and subcutaneous Sumatriptan in managing acute migraine attacks. Methods: This double-blind randomized clinical trial divided 90 patients into two groups: one group received 400 mg of intravenous SV a...

Sensitive, accurate and precise methods for the qauantitative determination of Seven drugs viz., Cyclobenzaprine HCl (CYC), Cyproheptadine HCl (CYP), Dobutamine HCl (DOB), Moxifloxacin HCl (MOX), Pamiprioxole HCl (PAM), Sumatriptan succinate (SUM) and Trimetazadine 2HCl(TRI) haave been developed . The methods are based on the charge transfer interqction of iodine with drugs which resulted in th...

Sumatriptan, a serotonin-1 receptor agonist specially developed for migraine, became available as a licensed product for adults more than 20 years ago. Since then, numerous controlled studies with sumatriptan have been carried out and it is widely used in adults. However, the story has not been as successful in children and adolescents as in adults. Of the few studies performed, most have shown...

normal 0 false false false en-us x-none ar-sa background: there are different options to manage benign headache in the emergency department. the costs, side effects, and efficacies of the drugs used are significantly different. the aim of this study was to compare intravenous (iv) metoclopramide with subcutaneous (sc) sumatriptan in treatment of migraine headache. material and methods: in a ran...