نتایج جستجو برای: sumo1
تعداد نتایج: 347 فیلتر نتایج به سال:
Small ubiquitin-like modifier proteases 1 and 2 (SUMO1/2) have been linked to the regulation of salicylic acid (SA)-mediated defence signalling in Arabidopsis thaliana. In order to define the role of the SUMO proteases OVERLY TOLERANT TO SALT1 and -2 (OTS1/2) in defence and to provide insight into SUMO1/2-mediated regulation of SA signalling, we examined the status of SA-mediated defences in ot...
Autophagy plays a deleterious role in ischemic myocardial injury. The deacetylase SIRT1 is well-established regulator of autophagy that can be modified by the ubiquitin-like protein SUMO1. Our previous work demonstrated another protein, FAT10, exerts cardioprotective effects against ischemia stabilizing caveolin-3 protein; however, FAT10 on through are unclear. Here, we constructed Fat10-knocko...
objective(s):small ubiquitin-like modifiers (sumos) are a family of ubiquitin-related, proteins that are involved in a wide variety of signaling pathways. sumoylation, as a vital post translational modification, regulate protein function in manycellular processes. diazinon (dzn), an organophosphate insecticide, causses oxidative stress and subsequently programmed cell death in different tissues...
Pax-6 is an evolutionarily conserved transcription factor regulating brain and eye development. Four Pax-6 isoforms have been reported previously. Although the longer Pax-6 isoforms (p46 and p48) bear two DNA-binding domains, the paired domain (PD) and the homeodomain (HD), the shorter Pax-6 isoform p32 contains only the HD for DNA binding. Although a third domain, the proline-, serine- and thr...
Recent studies have shown that sumoylation is a posttranslational modification involved in regulation of the transforming growth factor-β (TGF-β) signaling pathway, which plays a critical role in renal fibrosis in diabetic nephropathy (DN). However, the role of sumoylation in the regulation of TGF-β signaling in DN is still unclear. In the present study, we investigated the expression of SUMO (...
INTRODUCTION Sumoylation is involved in nucleolus-nucleoplasm transport of DNA topoisomerase I (topo I), which may associate with changes of cellular and topo I functions. Skin fibroblasts of patients with systemic sclerosis (SSc) exhibit profibrotic cellular changes. The aims of this study were to examine the catalytic function and sumoylation of topo I in the nuclei of SSc fibroblasts, a majo...
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