The number of melanocytic nevi is the most important risk factor for cutaneous melanoma. This 1998 cross-sectional study of 1,812 children aged 2-7 years from 78 day-care centers in Germany analyzed the protective effect of sunscreen and clothing on the number of melanocytic nevi. Total body nevi were counted, and pigmentary features were assessed. Parents underwent a standardized interview con...

CONTEXT High nevus density is a risk factor for cutaneous malignant melanoma. Melanocytic nevi originate in childhood and are largely caused by solar exposure. OBJECTIVE To determine whether use of broad-spectrum, high-sun protection factor (SPF) sunscreen attenuates development of nevi in white children. DESIGN Randomized trial conducted June 1993 to May 1996. SETTING AND PARTICIPANTS A ...

INTRODUCTION Skin photoaging is the consequence of solar UV exposure, and DNA damage is an important part of this process. The objective of the current work was to demonstrate that in vitro skin models can be utilized to confirm that DNA damage protection is provided by sunscreens. METHODS Skin equivalents were exposed to full-spectrum UV light administered with a standard research solar simu...

A 2-year-old boy with a history of atopic dermatitis presented with acute dermatitis on the areas where he had applied the sunscreen product Avène spray® 50+ (Eau Thermale Avene, Avène, France). The reaction, which had started to appear 10min after he had applied the cream, was described as “sunburn”. It lasted for a few days, and improved with corticosteroid cream application. Patch tests were...

The objective of present work was to develop novel sunscreen creams containing polymeric nanoparticles (NPs) of morin. Polymeric NPs containing morin were prepared and optimized. The creams containing morin NPs were also prepared and evaluated. Optimized NPs exhibited particle size of 90.6 nm and zeta potential of -31 mV. The entrapment efficiency of morin, within the polymeric NPs, was found t...

Sunscreen use is recommended for the prevention of sunburn and skin cancer. Little is known regarding sunscreen availability in high versus low income communities. We analyzed sunscreen availability in three large metropolitan counties to determine the relationship between availability and community demographics. We included sun care products in all pharmacies and supermarkets open as of July 2...

The p53 gene is a tumor suppressor gene that is commonly mutated in skin cancer and sun-exposed skin, and this can be detected through immunohistochemical expression of the p53 protein. The authors hypothesized that time spent outdoors is associated with p53 protein expression in human skin and that sunscreen use counteracts the association. In 1996, they investigated this in a community-based ...

The risk of microbial contamination in the cosmetic products especially in smuggled preparations and transmission of it to consumers is very high. In this study, the microbial content and the pollution of some sunscreen creams in the market and one sample in official market as witness were evaluated. The microbial content (bacterial total count, fungal count, and presence of Pseudomon asaerogin...

BACKGROUND In epidemiologic studies, sunscreen use is associated with increased risk of cutaneous melanoma, basal cell skin cancer, and higher numbers of nevi. It has been proposed that sunscreens may encourage prolonged sun exposure because they delay sunburn occurrence. We examined whether, under habitual conditions of sunscreen use, the sun-protection factor (SPF) had an influence on sun-exp...