Chlorogenic acid, found in robusta green coffee beans, is an antidiabetic agent. It made into bean extract tablets which are varied with 3 concentrations of sodium starch glycolate (SSG) as a disintegrant. This paper aimed to determine the effect variations concentration (4%, 6%, 8%) on physical characteristics granules (particle size distribution, flow properties, angle repose and compressibil...

Tablets with 250 mg of Rhodiola rosea L. extract disintegrating in less than 10 min were developed. The influence of the extract content and type of fillers and disintegrants on disintegration time and tablet hardness was evaluated. Type of the filler and the extract/filler ratio but not the type of disintegrant determined fast disintegration of the tablets. It was demonstrated that the extract...

This study was performed to design bilayer regioselective floating tablets of atenolol and lovastatin to give immediate release of lovastatin and sustained release of atenolol. Bilayer floating tablets comprised two layers, i.e immediate release and controlled release layers. The immediate release layer comprised sodium starch glycollate as a super disintegrant and the sustained release layer c...

This study was performed to design bilayer regioselective floating tablets of atenolol and lovastatin to give immediate release of lovastatin and sustained release of atenolol. Bilayer floating tablets comprised two layers, i.e immediate release and controlled release layers. The immediate release layer comprised sodium starch glycollate as a super disintegrant and the sustained release layer c...

Physical or chemical interactions between drug product (DP) components can occur during manufacturing and/or upon storage; and may alter DP shelf life performance. In this work a new Powder X-ray Diffraction (PXRD) peak was observed in under accelerated storage conditions. Due to the complex matrix (including API, polymer, fillers, super disintegrant lubricant), it challenging pinpoint componen...

Accepted May 17, 2012 The present research work deals with the development of a time delayed chronotherapeutic formulation of felodipine (FD) aimed at rapid drug release after a desired lag time in the management of hypertension. The developed system comprises a drug core embedded within a swellable layer and coated with an insoluble, water permeable polymeric system. FD cyclodextrin complex wa...

The present research work deals with the development of a time delayed chronotherapeutic formulation of felodipine (FD) aimed at rapid drug release after a desired lag time in the management of hypertension. The developed system comprises a drug core embedded within a swellable layer and coated with an insoluble, water permeable polymeric system. FD cyclodextrin complex was used as an active co...