Superoxide dismutase activity has been identified in both human neutrophils and rabbit alveolar macrophages by two distinct assay procedures. The enzyme is insensitive to both cyanide and azide and is present in the cytosol of the cell. The identification of this enzyme in phagocytic cells is compatible with the theory that superoxide anion might be involved in the bactericidal activity of the ...

The intracellular localization of Cu,Zn superoxide dismutase (superoxide:superoxide oxidoreductase, EC 1.15.1.1) has been examined by immunofluorescence using four monoclonal anti-Cu,Zn superoxide dismutase antibodies raised against a recombinant human Cu,Zn superoxide dismutase derivative produced and purified from Escherichia coli. Colocalization with catalase, a peroxisomal matrix enzyme, wa...

SOD2 encodes manganese superoxide dismutase, a mitochondrial enzyme that protects the cell against damage from superoxide free radicals. A common polymorphism, a T ! C transition (Val16Ala), was shown to alter the manganese superoxide dismutase mitochondrial targeting sequence (1). Animal studies have linked reduction in manganese superoxide dismutase activity to increased DNA damage and higher...

SOD2 encodes manganese superoxide dismutase, a mitochondrial enzyme that protects the cell against damage from superoxide free radicals. A common polymorphism, a T ! C transition (Val16Ala), was shown to alter the manganese superoxide dismutase mitochondrial targeting sequence (1). Animal studies have linked reduction in manganese superoxide dismutase activity to increased DNA damage and higher...

superoxide dismutase (sod) is an important antioxidant that protects many types of cells from the free radical damage. one of the possible ways for the use of sod is its incorporation in liposomes. the aim of this study was to investigate the effect of cationic phospholipids on the entrapment of human erythrocyte superoxide dismutase (cu/zn sod) in liposomes. also, in the present study, we exam...

      Superoxide dismutase (SOD) is an important antioxidant that protects many types of cells from the free radical damage. One of the possible ways for the use of SOD is its incorporation in liposomes. The aim of this study was to investigate the effect of cationic phospholipids on the entrapment of human erythrocyte superoxide dismutase (Cu/Zn SOD) in liposomes. Also, in the present study, w...

background: the purpose of this comparative study was to detect superoxide dismutase (sod) activities in fasciola hepatica, f. gigantica parasites, infected and healthy liver tissues in order to determine of species effects and liver infection on sods activity level. methods: fasciola spp. parasites and sheep liver tissues (healthy and infected liver tissues), 10 samples for each, were collecte...

INTRODUCTION studies show changes in zinc metabolism in women with breast cancer. This mineral has antioxidant action, and disorders in its biochemical parameters are related to poor prognosis of the disease and increase in the carcinogenic process. OBJECTIVE this study evaluated the activity of enzyme superoxide dismutase and biochemical parameters related to zinc, and investigated the exist...