Causes of initiation and progression of sporadic Alzheimer's disease (sAD) are likely multiple and include impairment of mitochondrial bioenergetics. We analyzed RNA expression levels of multiple mitochondrial oxidative phosphorylation (OXPHOS) and biogenesis (mitobiogenesis) genes in unfixed hippocampal (WH) frozen sections (10 sAD; 9 CTL) and laser-captured hippocampal pyramidal neurons (PyNs...

Erythrocyte sickling on deoxygenation in vitro occurs in transgenic SAD mice, hemizygous for a modified human sickle hemoglobin, HbSAD [alpha 2 beta 2S(beta 6val)Antilles (beta 23 lle)D- Punjab (beta 121Gln)] (SAD-1, 19% HbSAD; beta-thal/SAD-1, 26% HbSAD). The present study examines the cellular defects in vivo and pathologic changes observed in SAD-1 mice at atmospheric oxygenation as well as ...

Materials and Methods: Prospective study of traumatic subtrochanteric fractures of femur was carried out among 36 patients at department of Orthopaedics, New Civil Hospital, Surat during January 2013 to December 2014. During surgery, reduction was aimed by closed techniques but when required direct or indirect methods were applied as deemed necessary. Reduction of medial wall and calcar buttres...

A patient of tuberculous osteomyelitis of the bone flap following craniotomy for acute subdural hemorrhage which was treated at Surat Municipal Institute of Medical Education & Research (SMIMER) from June 2010 has been reported. This report emphasizes the fact that while treating osteomyelitis of bone flap following craniotomy, possibility of tuberculosis should be considered, especially in our...

This briefing paper provides an overview of issues related to kratom legislation and policy in Thailand as well as a set of conclusions and recommendations to contribute to a reassessment of the current ban on kratom in Thailand and the region. The briefing is based on desk research of existing documentation as well as field research carried out in October and November 2010 in Bangkok, Surat Th...

on the 28th day, one on the 19th day, and one on the 22nd day of the illness, each one with a varying degree of hepatic enlargement. In each case the liver has been more than three fingers below the right costal arch. The one seen on the 28th day had also an enlarged and tender gall-bladder. This hepatic enlargement has been extremely tender and painful, causing marked restlessness and hiccup, ...

There is a strong and optimistic commitment by all staff to the school improvement strategy and a clear belief that further improvement is possible. Teachers take responsibility for the changes in their practice required to achieve school targets and are using data on a regular basis to monitor the effectiveness of their own efforts to meet those targets. The school has developed an agenda for ...

Seasonal affective disorder or SAD is a recurrent major depressive disorder with a seasonal pattern usually beginning in fall and continuing into winter months. A subsyndromal type of SAD, or S-SAD, is commonly known as "winter blues." Less often, SAD causes depression in the spring or early summer. Symptoms center on sad mood and low energy. Those most at risk are female, are younger, live far...

Social Anxiety Disorder (SAD) is a chronic, disabling and treatable disorder with common onset in adolescence. Virtually there are no Indian studies on SAD. The study was conducted to find out frequency, demographic and phenomenological characteristics of SAD, family related risk factors, academic impairment and comorbidity of depression among adolescents. 421 adolescents in one high-school wer...