It has been shown by Freudenburg and Gyorgy that dried preparations of cartilage can take up certain cations from solution (l), and that in the case of calcium and magnesium this reaction can be followed by a similar reaction involving phosphate (2). On the other hand, it has been claimed by Roche and Deltour (3) that cartilage first binds phosphate and that this may be followed by a binding of...

The variability of quartz hazard is related to the characteristics of particulate toxicants. Although these have the same chemical composition, they exist in various forms and surface states, each one eliciting different biological responses. On the basis of data from the literature, surface chemical properties are associated to the subsequent stages reported by Donaldson and Borm (1998) in the...

It was shown by Loeb (1) that an approximate correspondence exists between the isoelectric points of gelatin or of egg albumin when in solution or adsorbed on the surfaces of microscopic particles. It remained for Abramson (2) to demonstrate a quantitative agreement between his own results for the electric mobility of serum albumin adsorbed on quartz surfaces and measured by the microscopic met...

Whereas the previous chapters focused mainly on the physical basics of surface plasmon resonance, instrumentation and assay design, we will now turn to the heart of SPR and related biosensors: the sensor chip and its surface chemistry. It is here where the biomolecular interaction takes place and although dimensionally extremely small (the coating thickness is measured in nanometers), the senso...

This article reveals the enabling aspects of nanografting (an atomic force microscopy-based lithography technique) in surface physical chemistry. First, we characterize self-assembled monolayers and multilayers using nanografting to place unknown molecules into a matrix with known structure or vice versa. The availability of an internal standard in situ allows the unknown structures to be image...