The aim of present study was the assessment of antimicrobial activity of prepared time-dependent release bilayer tablets of amoxicillin trihydrate and in vitro evaluation of drug release by antimicrobial assay using agar plate diffusion method. The bilayer tablets comprised of a delayed and sustained release layer. Direct compression method was used for the preparation of bilayer tablets contai...

The present study aimed to formulate and evaluate sustained release matrix tablets of levofloxacin to achieve sustained drug release with reduced side effects and improved patient compliance. Different batches of sustained release matrix tablets of levofloxacin were prepared by direct compression method using HPMC, sodium CMC and sodium alginate as polymers, Avicel PH 102 (MCC) as filler and st...

Inhalation of foreign bodies is a well recognised problem' but, surprisingly, the aspiration of tablets is rarely reported. There have been two reports in foreign publications of aspiration of sustained release tablets,23 which because of their formulation can remain intact in the respiratory tract for prolonged periods. We report two cases in which sustained release bronchodilator tablets have...

To examine newly developed single-unit of oral sustained release dosage form Simvastatin (SS) have been prepared by the wet granulation method. The hydrophilic matrix was prepared with xanthan gum with additives MCC PH101. On the in vitro drug release was studied. The studies indicated that the drug release can be modulated by varying the concentration of the polymer and fillers. Various pharma...

the purpose of this study was to develop a new monolithic matrix tablet to completely deliver glipizide in a zero order manner over a sustained period. two approaches were examined using drug in a formulation that contain polymer like hydroxylpropyl methyl-cellulose k 100 (hpmck) and eudragit l 100. the granules were prepared by wet granulation method and thereby formulated as f-1, f-2. f-3 and...

Tablets containing metoprolol succinate and Compritol®888ATO in the ratio of 1:2 yielded the desired sustained release profile in phosphate buffer pH 6.8 when evaluated using USP type II paddle apparatus and was selected as the optimized formulation. Robustness of optimized formulation was assessed by studying the effect of factors like varying source of metoprolol succinate and Compritol®888AT...

PURPOSE The aim of the present study was to improve the bioavailability of itopride (ITO) and sustain its action by formulating as a floating dosage form. MATERIALS AND METHODS Sustained-release floating tablets of ITO hydrochloride (HCl) were prepared by direct compression using different hydrocolloid polymers such as hydroxypropyl methylcellulose and ethylcellulose and/or methacrylic acid p...

Background and purpose of study: In the present investigation, an attempt was made to increase therapeutic effectiveness, reduce dose frequency and improvement in patient compliance, by developing sustained release matrix tablets of Diclofenac sodium using tamarind gum as release modifier. Methods: Six batches of sustained release matrix tablets of Diclofenac sodium were prepared by using diffe...