A swab-sampling method was developed for cleaning validation of a residual active pharmaceutical ingredient in samples collected after cleaning the sampling suite. A summary of the strategies and results of the method development is presented. The developed extraction method produced an acceptable level of recovery and precision. ross contamination with active ingredients is a real concern. The...

Objective : An attempt was made to compare the detection of cervical abnormalities between the use of a cotton swab and a Cervex brush in mass cancer screening. Study Design : Of 15,664 women who participated in a cervical cancer screening program in 2002, 8,366 women underwent Cervex brush sampling and 7,298 underwent cotton swab screening to compare the detectability of dysplasia and cancer i...

Levels of HIV-1 RNA in endocervical specimens fluctuate with the menstrual cycle, suggesting that cell-free HIV-1 levels may vary during the cycle, which could influence infectivity. Here, we examined daily changes in endocervical HIV-1-infected cells during 1 cycle. There were significant positive associations between the number of days from the luteinizing hormone surge and the number of HIV-...

BACKGROUND The role of the sino-nasal microbiome in CRS remains unclear. We hypothesized that the bacteria within mucosal-associated biofilms may be different from the more superficial-lying, free-floating bacteria in the sinuses and that this may impact on the microbiome results obtained. This study investigates whether there is a significant difference in the microbiota of a sinonasal mucosal...

OBJECTIVE This prospective study aims to compare three different sampling techniques for the collection of endometrial cytological specimens in the mare: the guarded culture swab, the uterine cytobrush and the low volume uterine flush. MATERIAL AND METHODS The study population consisted of six healthy Standardbred mares in dioestrus. In each mare an acute endometritis was induced by performin...

Prescribing systemic antibiotics without susceptibility testing has significant shortcomings, especially in long term care facilities with high rates of multidrug-resistant organisms (MDROs) including methicillin-resistant Staphylococcus aureus. Tissue biopsy or aspiration sampling of infected tissue is the "gold standard" for culture of skin and soft tissue infection and is especially importan...

Objective: This prospective study aims to compare three different sampling techniques for the collection of endometrial cytological specimens in the mare: the guarded culture swab, the uterine cytobrush and the low volume uterine flush. Material and methods: The study po pulation consisted of six healthy Standardbred mares in dioestrus. In each mare an acute endometritis was induced by performi...