A central problem in systems biology is to identify parameter values such that a biological model satisfies some behavioral constraints (e.g., time series). In this paper we focus on parameter synthesis for hybrid (continuous/discrete) models, as many biological systems can possess multiple operational modes with specific continuous dynamics in each mode. These biological systems are naturally ...

A central problem in systems biology is to identify parameter values such that a biological model satisfies some behavioral constraints (e.g., time series). In this paper we focus on parameter synthesis for hybrid (continuous/discrete) models, as many biological systems can possess multiple operational modes with specific continuous dynamics in each mode. These biological systems are naturally ...

In this paper, we present a constraint transformation and topology selection methodology that explores the system level parameter space to compute acceptable regions in the component parameter space. The search process of an underlying circuit synthesis tool could be con ned to these regions of valid solutions. Experimental results showing the impact of parameter space exploration at a higher l...

The parameter synthesis problem for timed automata is undecidable in general even for very simple reachability properties. In this paper we introduce restrictions on parameter valuations under which the parameter synthesis problem is decidable for LTL properties. The proposed problem could be solved using an explicit enumeration of all possible parameter valuations. However, we introduce a symb...