Systemic sclerosis (SSc) is a chronic autoimmune disorder characterized by progressive fibrosis of the skin and visceral tissues as well as a noninflammatory vasculopathy. Vascular disease in systemic sclerosis is a major cause of morbidity and mortality among nonpregnant patients with SSc and is even a bigger concern in the pregnant SSc patient, as the underlying vasculopathy may prevent the r...

O the past few decades survival in patients with SLE has gradually improved in the Western world. Under optimal conditions of diagnosis and supervised treatment, with good social support, life-expectancy can be as high as 0% at 10 years.1 Although there have been a dramatic improvement in the short term prognosis with proper immunosuppression and care of infection, the mortality rates in patien...

Successful endodontic practice requires complete knowledge about the various medical conditions and appropriateness in planning treatment as per the need with effective safety measures. This review focuses on a number of systemic complications encountered in endodontic practice and directions to be followed for avoiding potential complications. A detailed PubMed search was carried out using spe...

A fulminant case of endophthalmitis due to Clostridium septicum is described. The patient presented with spontaneous gas gangrene panophthalmitis, with early visual loss and an air bubble in the anterior chamber. Death ensued, and necropsy revealed changes consistent with severe arterosclerotic cardiovascular disease, a relationship not uncommon in patients with clostridium sepsis. This associa...

Incidence The frequency of various systemic complications of ulcerative colitis was studied in the series of 465 patients investigated in Leeds between 1948 and 1963 by de Dombal and his colleagues. Skin lesions occurred in twenty-nine patients (6 2%), colitic arthritis in fifty-six patients (12-0%), sacro-iliitis in forty-two patients (18%) and florid spondylitis in thirteen patients (6%). Eye...

This brief monograph is an excellent review of the extra-articular manifestations of rheumatoid arthritis from the standpoint of diagnosis, therapy and relationship to the overall features of the disease. Most of the material comes from published reports and reviews in individual areas, embellished by Dr. Hollingsworth's personal experience while he was Chief of Rheumatology at the Yale Univers...

Complex Regional Pain Syndrome (CRPS) is a neuropathic pain disorder that is characterized by: 1) Severe pain beyond the area of injury; 2) Autonomic dysregulation; 3) Neuropathic edema; 4) A movement disorder, atrophy and dystrophy. It is most often caused by a fracture, soft-tissue injury or surgical procedure and is divided into Type I, in which no nerve lesion is identified (classic reflex ...