local inflammatory processes in the gastric mucosa are followed by extensive immune cell infiltration, resulting in chronic active gastritis characterized by a marked infiltration of t(h)1 cytokine-producing cd4+ and cd8+t-cells objective. to investigate the correlation between cd4+/cd8+ t-cells in gastric mucosa with endoscopic appearance in chronic gastritis with or without h.pylori infection...

abstractbackgroundcontributes substantially to patient morbidity and mortality.in this study we investigatedthe range and distribution of t-lymphocyte. subsets cd3helper/inducer cell,.th ), cd8: severe immunosuppression occurs after large thermal burn and probably+ (t cells) cd4+ (t+ (t suppressor /cytotoxic cells ,ts/c), cd3+cd4thermal injury.+/cd3+cd8+ ratio, cd19+ (b cells) and cd16+ (nk cel...

background: determination of the division history of t cells in vitro is helpful in the study of effector mechanisms against infections. technique described here uses the intracellular fluorescent label carboxyfluorescein diacetate succinimidyl ester (cfse) to monitor the proliferation. methods: in a cross sectional study, blood samples were collected from 7 volunteers with history of cutaneous...

back ground: candida albicans is a member of the normal human microflora. c. albicans cell wall is composed of several protein and carbohydrate components which have been shown to play a crucial role in c. albicans interaction with the host immune system. major components of c. albican cell wall are carbohydrates such as mannans, β glucans and chitins, and proteins that partially modulate the h...

background: type 1 diabetes (t1d) is a t cell mediated autoimmune disease targeting the insulin-producing β cells within pancreatic islets. autoimmune diseases may develop as a consequence of altered balance between regulatory (tregs) and autoreactive t cells. objectives: to evaluate treg cells frequency and suppressive function in the peripheral blood of newly diagnosed t1d patients in compari...

Chimeric antigen receptor engineered-T (CAR-T) cells also named as living drugs, have been recently known as a breakthrough technology and were applied as an adoptive immunotherapy against different types of cancer. They also attracted widespread interest because of the success of B-cell malignancy therapy achieved by anti-CD19 CAR-T cells. Current genetic toolbox enabled the synthesis of CARs ...

mitochondrial functions have a major impact on t-cell functionality. in this study we characterized whether mitochondrial function in the neonatal t-cells differs from that in the adult t-cells during short t-cell activation. methods: we used fow cytometry methods to test mitochondrial mass and to monitor mitochondrial ca2+ levels, mitochondrial potential and superoxide generation in parallel w...