The scaffolding core in bacteriophages is a temporary structure that plays a major role in determining the shape of the protein shell that encapsulates the viral DNA. In the currently accepted structure for the scaffolding core in bacteriophage T4, there is a symmetry mismatch between the protein shell, which has fivefold symmetry, and the scaffolding core, which is believed to consist of six h...

Phage T4 is known to have a linear duplex chromosome that is circularly permuted and terminally repeated. We found, by denaturation and self-reannealing experiments, that circular permutation in T4 native DNA is not random. Their multimodal distribution of permutation is compatible with the "headful packaging" model with the additional specifications that the encapsulation of DNA starts at seve...

A semiautomatic procedure is presented for the separate determination of total T3 and T4 in serum in approximately 10 hrs simultaneously in 25 samples. Removal of the thyroid hormones from the serum, separation of T3 from T4 and concentration of the peaks were achieved in a closed system, consisting of three consecutive columns. The automatic microchemical iodine determination of T3 and T4 resp...

The Escherichia coli 30S ribosomal protein P10, the product of the str gene, known to be involved only in the initiation of protein syntehsis, is required for all bacteriophage T4 protein synthesis.