PURPOSE To compare the safety and efficacy of fixed-dose tafluprost/timolol combination (Taf/T-FDC) with those of fixed-dose latanoprost/timolol combination (Lat/T-FDC) by measuring the intraocular pressure (IOP)-lowering effect, ocular pharmacokinetics, and ocular surface toxicity. METHODS The IOP-lowering effect of Taf/T-FDC and Lat/T-FDC in ocular normotensive monkeys was evaluated at 4 an...

Determination of the crystal structure of the human TBP-associated factor (hTAF(II))28/hTAF(II)18 heterodimer shows that these TAF(II)s form a novel histone-like pair in the TFIID complex. The histone folds in hTAF(II)28 and hTAF(II)18 were not predicted from their primary sequence, indicating that these TAF(II)s define a novel family of atypical histone fold sequences. The TAF(II)18 and TAF(II...

Background: Recent evidence suggests that integrase strand transfer inhibitors are associated with greater weight gain than protease in patients human immunodeficiency virus (HIV-1). Objectives: To describe demographic and clinical characteristics of insured HIV-1 the United States initiating darunavir/?cobicistat/?emtricitabine/?tenofovir alafenamide (DRV/c/FTC/TAF) or bictegravir/FTC/TAF (BIC...

We study the effects of the U.S. Federal Reserve’s Term Auction Facility (TAF) on globally active banks. We exploit a unique dataset with information on all foreign activities of German banks’ affiliates both, inand outside the US. All German parent banks with US affiliates tapped TAF liquidity, which mitigates self-selection concerns. This setting allows testing whether foreign affiliate activ...

The aim of the study was to investigate the possibility of improving the therapeutic efficacy of the total alkaloid fraction (TAF) extracted from processed nux vomica by reducing the strychnine contents. Most strychnine was removed from TAF to obtain the modified total alkaloid fraction (MTAF). The toxicity and pharmacokinetics of TAF and MTAF were further investigated and compared besides thei...

The general transcription factor TFIID is composed of the TATA box binding protein (TBP) and multiple TBP-associated factors (TAFs). In yeast, promoters can be grouped into two classes based on the involvement of TAFs. TAF-dependent (TAF(dep)) promoters require TAFs for transcription, and TBP and TAFs are present at comparable levels on these promoters. TAF-independent (TAF(ind)) promoters do n...

Independent security functional testing on a product occupies a backseat in traditional security evaluation because of the cost and stringent coverage requirements. In this paper we present the details of an approach we have developed to automate security functional testing. The underlying framework is called TAF (Test Automation Framework) and the toolkit we have developed based on TAF is the ...

c-Jun is an oncoprotein that activates transcription of many genes involved in cell growth and proliferation. We studied the mechanism of transcriptional activation by human c-Jun in a human RNA polymerase II transcription system composed of highly purified recombinant and native transcription factors. Transcriptional activation by c-Jun depends on the TATA-binding protein (TBP)-associated fact...

OBJECTIVE To determine whether increased serum and/or tracheal aspirate fluid (TAF) levels of IL-6 at birth are associated with fetal inflammation in ventilated extremely low gestational age newborns (ELGAN). METHOD A total of 36 ELGAN who required mechanical ventilation were enrolled in this study. The patients were classified into two groups: 19 infants who displayed histological evidence o...

TAF(II)250, the largest subunit of the general transcription factor TFIID, is expressed from the human X chromosome, at least in somatic cells. In male meiosis, however, the sex chromosomes are transcriptionally silenced, while the autosomes remain active. How then are protein-encoding genes transcribed during human male meiosis? Here we present a novel autosomal human gene, TAF1L, which is hom...