When 3 x 10(8) bacteria of the Escherichia coli tyrA14(oc) leu308(am) strain WU3610 are plated on glucose salts agar supplemented with leucine only, colonies of slow-growing Tyr+ suppressor mutants begin to appear after about a week and increase in numbers roughly linearly with time thereafter (stationary phase or starvation-associated mutation). From a library constructed from two of these mut...

BACKGROUND TAS-102, a new treatment option for patients with metastatic colorectal cancer that is refractory or intolerant to standard therapies, has been improving survival with acceptable tolerability and adverse events. Adverse hematological events associated with TAS-102 treatment were extensively profiled in the RECOURSE trial, but pulmonary toxicities associated with TAS-102 therapy are d...

Prolidase deficiency has been related to mental retardation and oxidative stress. The study aimed to observe plasma prolidase activity (PPA), total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) in patients with Parkinson's disease (PD). 240 subjects with PD and 150 healthy volunteers were considered as cases and controls, respectively. PPA, TOS, TAS, and...

BACKGROUND Reactive oxygen species (ROS) have been proposed to play important pathogenic roles, especially in harmful oxidative modifications of low-density cholesterol. Redox balance within the organism is largely determined by the activities of anti-oxidative enzymes of red blood cells and by the total anti-oxidative capacity of the serum (TAS). MATERIAL/METHODS SOD and GPx activities and T...

Unusual regions of densely packed membranous tubules known as tubular aggregates (TAs) have been observed in skeletal muscle fibres of mammals under numerous pathological conditions but also in health. Their causality is unclear. It is neither known whether TAs are destructive and should be treated or whether they have a compensating function in an endangered muscle. In spite of many similariti...

(7 )-21-[4-[(Diethylamino)methyl]-2-methoxyphenoxy]-7-methyl19-norpregna-1,3,5(10)-trien-3-ol 2-hydroxy-1,2,3-propanetricarboxylate (TAS-108) is a novel steroidal antiestrogen, modulating the differential recruitment of transcriptional cofactors by liganded estrogen receptors and representing a promising agent for the treatment of breast cancer. To understand better the relationships between th...

Thirty-three premature and full-term infants (PCA, 31.5 to 50 weeks) who were free from neurologic and cardiopulmonary disease at the time of testing underwent a standardized TAS test during polygraphically controlled REM sleep. The R-R interval and the TTOT were measured before and during TAS. The R-R interval and TTOT changes during TAS were compared to the preceding 60-second mean R-R interv...

CSIRO Oceans and Atmosphere Business Unit, Brisbane, QLD, Australia, 2 Institute for Marine and Antarctic Science, University of Tasmania, Taroona, TAS, Australia, CSIRO Oceans and Atmosphere Business Unit, Hobart, TAS, Australia, 4 Tasmanian School of Business and Economics, University of Tasmania, Hobart, TAS, Australia, 5 School of Economics and Finance, Queensland University of Technology (...

OBJECTIVE Alexithymia, a common personality style of patients seeking psychotherapeutic help, is associated with illness severity and negative treatment outcome in various mental disorders. Still, it remains unclear how alexithymia influences psychopathology and the therapeutic processes. In previous studies, a strong association of alexithymia with self-directedness (SD), a dimension of Clonin...

The objective of this study was to compare the level of total antioxidant status (TAS) in type 2 diabetic and normal Palestinian subjects as well as the major factors influencing TAS levels. A sample of convenience composed of 212 type 2 diabetic and 208 normal subjects above the age of 40 were recruited. Only 9.8% of the subjects had normal body mass index (BMI) levels (<25), 29% were overweig...