نتایج جستجو برای: tbi bucy regimens
تعداد نتایج: 40000 فیلتر نتایج به سال:
Proceedings of the 2nd Meeting of the Asian Cellular Therapy Organization; Published online 30 Nov 2011 Adult acute lymphoblastic leukemia (ALL) is one of the intractable diseases in hematological malignancies, showing about 30% long-term survival by intensive chemotherapies with high incidence of relapse. Allogeneic hematopoietic stem cell transplantation (allogeneic HSCT) has been therefore a...
Traumatic brain injury (TBI) is one of the few known etiological factors contributing to the development of post-traumatic epilepsy (PTE). An understanding of the mechanisms involved in the development of PTE is vital because PTEs are amongst the most difficult to treat, and are often resistant to first and second line anti-epileptic treatment regimens. TBI-induced inflammation, neuroplasticity...
BACKGROUND Few studies thus far have compared head-to-head different non-myelooablative conditioning regimens for allogeneic hematopoietic cell transplantation (allo-HCT). METHODS Here, we report the results of a phase II multicenter randomized study comparing non-myeloablative allo-HCT from HLA-identical siblings (n = 54) or from 10/10 HLA-matched unrelated donors (n = 40) with either fludar...
Kalman-Bucy smoothers are often used to estimate the state variables as a function of time in a system with stochastic dynamics and measurement noise. This is accomplished using an algorithm for which the number of numerical operations grows linearly with the number of time points. All of the randomness in the model is assumed to be Gaussian. Including other available information, for example a...
Kluver-Bucy syndrome is an uncommon syndrome of behavioral abnormalities following bilateral temporal lobe injury. Only four children have been reported previously with this syndrome. We report three additional pediatric patients who developed Kluver-Bucy syndrome following hypoxic insults. In two patients, features of the syndrome were transient. Problems in intermediate memory were present in...
UCBT was performed in seven children with SCD and stroke (HLA match 4/6 n=5; 5/6 n=2). Four received myeloablative regimens (BU, CY, ATG plus FLU in one patient). One had primary graft failure, three had sustained engraftment, two with grade III-IV GVHD (one died, one developed chronic GVHD), one with stable mixed chimerism. Three patients treated with reduced-intensity regimens (FLU, BU or CY,...
Radioimmunotherapy offers an exciting new therapeutic modality for patients with relapsed non-Hodgkin's lymphoma; however, considerable debate exists regarding the optimal dose and administration schedule for radioimmunoconjugates. Myelosuppression has been the dose-limiting toxicity of most clinical trials employing radiolabeled antibodies, and this complication has generated both high-dose an...
Reduced intensity conditioning (RIC) is desirable for hematopoietic stem cell (HSC) gene therapy applications. However, low gene marking was previously observed in gene therapy trials, suggesting that RIC might be insufficient for (i) opening niches for efficient engraftment and/or (ii) inducing immunological tolerance for transgene-encoded proteins. Therefore, we evaluated both engraftment and...
In the era of precision medicine, the impact of personalized dosing of busulfan is not clear. We undertook a retrospective analysis of 78 patients with myeloid malignancies who received fludarabine and busulfan (FluBu4) with or without measuring Bu pharmacokinetics (Bu PK) and those who received busulfan with cyclophosphamide (BuCy). Fifty-five patients received FluBu4, of whom 21 had Bu PK mea...
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