A transient transfection system was used to identify regulators and effectors for Tec and Bmx, members of the Tec non-receptor tyrosine kinase family. We found that Tec and Bmx activate serum response factor (SRF), in synergy with constitutively active alpha subunits of the G12 family of GTP-binding proteins, in transiently transfected NIH 3T3 cells. The SRF activation is sensitive to C3, sugge...

The murine sak gene encodes a putative serine-threonine kinase which is homologous to the members of the Plk/Polo family. Although Sak protein is presumed to be involved in cell growth mechanism, efforts have failed to demonstrate its kinase activity. Little has been, therefore, elucidated how Sak is regulated and how Sak contributes to cell proliferation. Tec is a cytoplasmic protein-tyrosine ...

In this study, the characteristics of the total electron content (TEC) fluctuations and their regional differences over China were analyzed by utilizing the rate of the TEC index (ROTI) based on GPS data from 21 reference stations across China during a solar cycle. The results show that there were significant regional differences at different latitudes. Strong ionospheric TEC fluctuations were ...

[1] The long-duration positive ionospheric storm effect that occurred on 15 December 2006 is investigated using a combination of ground-based Global Positioning System (GPS) total electron content (TEC), TOPEX and Jason-1 TEC, and topside ionosphere/ plasmasphere TEC, GPS radio occultation, and tiny ionospheric photometer (TIP) observations from the Constellation Observing System for Meteorolog...

PURPOSE To compare refractive outcomes and higher order aberrations of eyes that underwent LASIK for myopia with astigmatism with or without active cyclotorsion error correction. METHODS This was a contralateral eye study of 48 eyes of 24 patients who underwent LASIK using the NIDEK Advanced Vision Excimer laser platform (NAVEX), treating one eye with active cyclotorsion error correction (TEC...

The Jun family and the signal transducers and activators of transcription (STAT) are involved in proliferation and apoptosis. Moreover, c-Jun and STAT3 cooperate to regulate apoptosis. Therefore, we used double immunostaining to investigate the immunotopographical distribution of phospho-c-Jun (p-c-Jun), JunB, JunD, p-STAT3, p-STAT5, and p-STAT6 in human thymus. JunD was frequently expressed by...

Fas, a cell surface receptor, can induce apoptosis after cross-linking with its ligand. We report that Fas antigen is constitutively expressed in medullary epithelial cells of the human thymus. Expression is decreased in cultured thymic epithelial cells (TEC), similarly to HLA-DR antigen. TEC are resistant to anti-Fas-induced apoptosis after 4 days of primary culture, and this resistance is rev...

Fas, a cell surface receptor, can induce apoptosis after cross-linking with its ligand. We report that Fas antigen is constitutively expressed in medullary epithelial cells of the human thymus. Expression is decreased in cultured thymic epithelial cells (TEC), similarly to HLA-DR antigen. TEC are resistant to anti-Fas–induced apoptosis after 4 days of primary culture, and this resistance is rev...