Congenital malformations now represent the largest single cause of mortality in the infant of the diabetic mother. The mechanism by which diabetes exerts its teratogenic effects is not known. This study evaluated whether arachidonic acid might be involved, a possibility raised by the role of arachidonic acid in palatal elevation and fusion, processes analogous to neural tube folding and fusion....

Methenamine salts have been traditionally used in the veterinary and human medicine, but its use is sometimes associated with some side effects.Toxicopathological effects of methenamine salt have always been a major concern. There is scantly information available about the lesions of methenamine compound in embryo. The objective of this study was to determine the teratogenic effects of methenam...

Drugs taken during pregnancy create concern whether they are self administered or medically prescribed. The number of mothers who take drugs during pregnancy is not known, but a survey in the United States showed that about 45% ofwomen may use at least one drug on prescription, and many more use drugs bought over the counter.' A recent prospective study in the United Kingdom, however, suggested...

Methotrexate is a drug that is used to treat rheumatoid arthritis, psoriatic arthritis, Reiter’s syndrome, acute lymphoblastic leukemia, ectopic pregnancy and other conditions. Since methotrexate is well known for its teratogenic effects in humans, the present study is conducted to observe its effect on chick embryos. A single injection of 0.012 mg of methotrexate was injected into the yolk sac...

Among the various exogenous agents inducing developmental anomalies in higher mammals, administration of chemicals to pregnant animals may be a suitable means for the detection of the mechanism of teratogenesis. Sinclair ('50) recognized an abnormality of the nervous system of embryos after treatment of pregnant mice of an albino stock for several days from 7-8th day of gestation, with ethyl-ur...

L I T T L E information is available in the literature on the susceptibility of the hamster embryo to teratogens. Desoxycorticosterone acetate apparently has some teratogenic activity (Tedford & Risely, 1950), but the degree and type of abnormality produced by this agent in the hamster have not been recorded. Orsini (1952) has described naturally-occurring urogenital anomalies which appear in f...