Background: Exposure to glucocorticoids such as dexamethasone (Dex) leads to numerous changes in various biological systems including the reproductive system. The present study investigates the efficacy of curcumin (Cur), an active component of turmeric, to attenuate Dex-induced spetmatogenic defects in the mouse testicles. Materials and Methods: A total of 32 male mice were divided into four g...

Background: Exposure to glucocorticoids such as dexamethasone (Dex) leads to numerous changes in various biological systems including the reproductive system. The present study investigates the efficacy of Alcoholic extract of grape seeds, an active component of turmeric, to attenuate Dex-induced spetmatogenic defects in the mouse testicles. Materials and Methods: A total of 32 male mice were d...

The aqueous extract of leaf of Aegle marmelos (Bael) at the dose 50 mg/100 g body weight resulted a significant diminution in the activities of testicular key steroidogenic enzymes along with low levels of plasma testosterone and relative wet weights of sex organs in respect to control without any significant alteration in general body growth. Germ cells numbers in different generation at stage...

Some morphometric parameters of the buffalo gonad and epididymis were compared in the mating (late autumn-winter) versus non-mating (late spring to the beginning of autumn) seasons. Organs from mature bulls of proven fertility were collected at slaughtering in February and September and used for this study. Testicular and epididymal diameters and weights were measured. The diameters of the test...

backgrounds: evidence is accumulating to support disruption of tissue architecture as a powerful event in tumor formation. for the past four decades, intensive cancer research with the premise of “cancer as a cell based-disease” focused on finding oncogenes or tumor suppressor genes. however, the role of the tissue architecture was neglected. three dimensional (3d) cell cultures which can recap...

objective: electroporation can be a highly efficient method for introducing the foreign genetic materials into the targeted cells for transient and/or permanent genetic modification. considering the application of this technique as a very efficient method for drug, oligonucleotide, antibody and plasmid delivery for clinical applications and production of transgenic animals, the present study ai...

The epithelial lining of the epididymal duct expresses the androgen receptor (Ar) along its entire length and undergoes rapid and profound degeneration when androgenic support is withdrawn. However, experiments involving orchidectomy with systemic testosterone replacement, and testicular efferent duct ligation, have indicated that structural and functional integrity of the initial segment canno...

Cisplatin is an effective chemotherapeutic drug used to treat many types of tumours. However, it may cause male reproductive toxicity. Gallic acid exhibits beneficial effects such as antioxidant, anti-inflammatory and antitumor. The current study investigated the gallic against testis epididymis toxicity induced by cisplatin. Male rats were divided into 4 groups follows (n = 7): Control, cispla...

We report a case of a psammomatous variant of meningioma arising in a pure and mature testicular teratoma. At immunohistochemistry, the meningiomatous component showed epithelial membrane antigen, S100 protein, and vimentin positive. Benign neoplasms arising in testicular teratomas are extremely rare. To our knowledge, we have not found any such report of psammomatous variant of meningioma in a...