Background: The recent years has seen enormous research attempts in the study for genetic factors that may predispose individuals to periodontitis, as one of the most common chronic infectious disease in humans. Objectives: The aim of the present study was to determine the breakdown of interdental gingiva tissues in chronic periodontitis patients with TGF-β1 (-509) C/T polymorphisms. Patients a...

Background: The 5, 10-methyleneterahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) are two essential enzymes involved in folate metabolism. The relationship between genetic polymorphisms and congenital heart defects (CHDs) is inconsistent. Our aim was to investigate the association between two well-known polymorphisms of MTHFR and MTRR genes, C677T and A66G, respectively,...

Objective(s):Organic anion transporter polypeptide 1B1 (OATP1B1) encoded by solute carrier organic transporter 1B1 (SLCO1B1) gene; a transporter involved in the uptake of drugs and endogenous compounds is present in hepatocyte sinusoidal membrane. Aim of this study was to investigate the frequencies of functionally significant SNPs (388A>G and 521T>C) and their haplotypes in 6 ethnic groups of ...

ERCC5 plays crucial role in excision repair DNA damage induced by UV in NER pathway. Single neuleotide polymorphism in ERCC5 were responsible for different cancers.Therefore, current study evaluated the relationship between ERCC5 (rs1047768 T>C) polymorphism and the risk of breast cancer in Pakistani population. The rs1047768 polymorphism was screened among 175 female...

conclusions the results revealed a significant relationship between the gg genotype of ctla-4 and the increased risk of tb. results data analysis indicated that the frequencies of aa, ag and gg genotypes were 42%, 38%, and 20% in patients with tb and 43%, 47%, 1% in the control subjects, respectively. the gg genotype of ctla-4 (+49a/g) showed a significantly increased risk of disease (or = 20.4...

ERCC5 plays crucial role in excision repair DNA damage induced by UV in NER pathway. Single neuleotide polymorphism in ERCC5 were responsible for different cancers.Therefore, current study evaluated the relationship between ERCC5 (rs1047768 T>C) polymorphism and the risk of breast cancer in Pakistani population. The rs1047768 polymorphism was screened among 175 female...

results using these two sets, we identified h1069q mutation in four patients, c.2335t > g mutation in three, c.3061-1g > a splice site mutation in five, c.3305t > c mutation in one, and c.3809a > g mutation in two patients. conclusions the multiplex arms assay used in this study can be an efficient, reliable, and cost effective method as a primary screen for patients with wilson disease. patien...

Background: Single-nucleotide polymorphism (SNP) rs2476601 within protein tyrosine phosphatase non-receptor type 22 gene (PTPN22) has been shown to be a risk factor for different autoimmune diseases. This study explored the association of 1858 C/T SNP with rheumatoid arthritis (RA) and celiac disease (CD) in a region covering south-west of Iran. Methods: Totally, 52 patients with CD, 120 patien...

Interleukin-6 (IL-6) is associated with inflammatory diseases, but its connection Cryptosporidium in Holstein calves remains unknown. This study aimed to investigate the effect of single nucleotide polymorphisms (SNPs) IL-6 on resistance and susceptibility prepare a phylogenetictree order show relation between species. Seventy-two samples were studied from healthy infected genotyped using tetra...

background: the association between interleukin‑6 (il‑6) (‑174g/c) gene polymorphisms and level of tissue breakdown and periodontal disease progression is unknown. the present study investigated quantitative parameters of interdental papilla in chronic periodontitis (cp) patients with il‑6 (‑174g/c) gene polymorphisms. materials and methods: sixty gingival samples were studied. after determinat...