OBJECTIVE The aim of this study was to carry out experiments further to our previous new formulation to modify the Leishmania major antigen that had satisfactory results previously. METHODS In this study we made a preliminary, new vaccine with the same methodology and selected two injection doses (100&200 μg/o.1 mL), three injection Groups: Leishmania plus BCG (LB), Leishmania plus new adjuva...

In the present study, protective effect of Teucrium polium L. (Labiatae) extract on acetaminophen-induced hepatotoxicity was investigated in mice. Animals were divided into six groups, each group consist of 8 mice. Group one as the negative control group received normal saline, while group two received only crude extract of T. polium L. (500 mg/Kg) for five days and group three as the positive ...

Objective. The effects of hydroalcoholic extract of Teucrium polium and metformin on diabetes-induced memory impairment and brain tissues oxidative damage were investigated. Methods. The rats were divided into: (1) Control, (2) Diabetic, (3) Diabetic-Extract 100 (Dia-Ext 100), (4) Diabetic-Extract 200 (Dia-Ext 200), (5) Diabetic-Extract 400 (Dia-Ext 400), and (6) Diabetic-Metformin (Dia-Met). G...

Teucrium polium L. (Labiatae) has long been recognized in folk medicine in the treatment of many pathophysiological implications, such as gastrointestinal disorders, inflammations, diabetes and rheumatism. In this study antimicrobial activity of two crude extracts obtained from Teucrium polium L. was tested against bacterial species. Minimum Inhibitory Concentration (MIC) and Minimum Bactericid...

Background and objectives: Amongst the serious metabolic disorders, diabetes mellitus (DM) is a common disease throughout the world. The excess of morbidity and mortality associated with DM and its complications emphasize the importance of new or alternative therapeutic strategies in prevention and treatment of this chronic disorder. Medicinal herbs grow vastly in Iran and are ...

Plant extracts are proved to possess many positive effects in cancer treatment. While many of commonly used therapeutics rely on cytotoxic methodologies, much less are based on positive influence on migrating potential of cancer cells, i.e. on antimetastatic grounds. Here, according to our knowledge, for the first time was investigated influence of Teucrium montanum L. and T. polium L. methanol...

The essential oil (EO) obtained by hydrodistillation from Teucrium polium L. was analyzed by gas chromatography and gas chromatography mass spectrometry (GC/MS). Antioxidant activity was evaluated through DPPH assay and Beta-carotene/linoleic acid assay. Twenty one components were identified representing (90.4%) of the EO. Main constituents of the essential oil were found as Spathulenol (15.06%...

abstract background:  primary dysmenorrhea is a prevalent problem and its effects decrease the quality of life in many women across the world. due to the side-effects of synthetic drugs, there is an increasing trend toward herbal medicine. the aim of this study was to research the effect of teucrium polium compared to placebo on the pain duration of dysmenorrhea.   materials and methods: this t...

Background. Teucrium polium is used in Arab traditional medicine to treat liver diseases. Glutathione is an important intracellular antioxidant, and intrahepatic glutathione levels are depleted in liver diseases. Hypothesis and Aim. This investigation tested the hypothesis that aqueous extracts of T. polium maintains intracellular glutathione levels by augmenting glutathione peroxidase and glut...