نتایج جستجو برای: thalassemia intermedia
تعداد نتایج: 23663 فیلتر نتایج به سال:
Methods Among the 956 women with hemoglobinopathies in reproductive age enrolled in the Myocardial Iron Overload in Thalassemia (MIOT) project, we selected 17 women with thalassemia (14 with thalassemia major and 3 with transfusion-dependent thalassemia intermedia) who had a pregnancy with successful delivery and who performed a MRI scan before and after the pregnancy. Myocardial and liver iron...
As the life expectancy of β-thalassemia patients has markedly improved over the last decade, several new complications are being recognized. The presence of a high incidence of thromboembolic events, mainly in thalassemia intermedia patients, has led to the identification of a hypercoagulable state in thalassemia. In this review, the molecular and cellular mechanisms leading to hypercoagulabili...
BACKGROUND beta-thalassemia is a rare disease in France, encountered mainly in patients originating from Italy and North Africa. In the setting of the recent French plan for rare diseases, a National Registry for thalassemia has been developed since 2005. Epidemiological and clinical data have been collected on living patients with beta-thalassemia major or intermedia, including those who under...
background recent studies regarding the effect of hydroxyurea (hu) in thalassemia have revealed favorable effects on the reduction of ineffective erythropoiesis. objectives the aim of the current study was to evaluate whether or not hu can have an effect on the gallstone formation rate in patients with beta-thalassemia intermedia (bti). patients and methods in this case control cross-sectional ...
The protein composition of ghosts. inside-out vesicles (by). and membrane skeletons (MS) of erythrocytes (ABC) from splenectomized (spx) and nonsplenectomized (nonspx) patients with $-thalassemia major and $-thalassemia intermedia was determined. Ghosts from spx thalassemia intermedia patients had a significant increase in their globin content (which was mostly heme reactive) and contained extr...
Background: Expansion of bone marrow cavity and decreased cortical and trabecular bone tissues and osteoporosis are resulted from beta-thalassemia. The aim of this study was to assess bone mineral density (BMD) in patients with β thalassemia major and intermedia, and to determine their biochemical and hormonal profiles that may affect BMD. Materials and Methods: In a cross sectional study from ...
background: expansion of bone marrow cavity and decreased cortical and trabecular bone tissues and osteoporosis are resulted from beta-thalassemia. the aim of this study was to assess bone mineral density (bmd) in patients with β thalassemia major and intermedia, and to determine their biochemical and hormonal profiles that may affect bmd. materials and methods: in a cross sectional study from ...
Mutations producing beta-thalassemia reach individual gene frequencies greater than .01 in malarial-endemic regions because beta-thalassemia trait individuals have increased genetic fitness over that of normal individuals. Exon 3 of the beta-globin gene has been relatively spared as a site of common beta-thalassemia mutations. Frameshifts caused by the loss of a single nucleotide and nonsense m...
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