OBJECTIVE The COBRA therapy (combination therapy in early rheumatoid arthritis) has proven to be an effective treatment for early RA, but is rarely prescribed. A survey showed reluctance of Dutch reumatologists to apply COBRA therapy in early RA. The present qualitative study was carried out to further explore the reservation of Dutch rheumatologists towards prescribing COBRA therapy and includ...

Complete List of Authors: Hofrichter, Jens; IBM Research Zurich Raz, Oded; COBRA Research Institute, Eindhoven University of Technology Liu, Liu; Photonics Research Group, INTEC, Ghent University—IMEC Morthier, Geert; Photonics Research Group, INTEC, Ghent University—IMEC Horst, Folkert; IBM Research Zurich Regreny, Philippe; Université de Lyon, Institut des Nanotechnologies de Lyon INLUMR5270,...

Literature, in addition to its aesthetic and artistic aspects, has always been a reflection of social and cultural realities and characteristics of its respective era and society. Sociological criticism is a relatively modern method in literary criticism. The method studies the structure and content of literary works and their relation to the structures and evolutions of the societies where the...

BACKGROUND Chronic pain often results in cognitive impairment. Our previous study showed that trigeminal neuralgia induced by cobra venom leads to spatial learning and memory deficits, although the underlying mechanism remains unclear. However, recent evidence indicates that the c-AMP-responsive element binding protein (CREB)/brain derived neurotrophic factor (BDNF) pathway plays a critical rol...

the myocardial effect of snake venoms is considered as one of the most common pathogenesis in many cases of snake envenomation. this study was under taken to investigate the effects of snake (naja naja oxiana) venom on cardiac function in experimental animals. the blood samples from all the rabbits were collected before venom injection and then 140 µg/kg venom of snake (naja naja oxiana) was in...

Although Chinese cobra snakebite is the most common type of snake venenation in China, it still lacks a comprehensive and systematic description. Hence, we aimed to study Chinese cobra bite cases with particular attention to demography, epidemiology and clinical profile. In this study, a total of 292 cases of Chinese cobra snakebite, presenting between January 1, 2008 and December 31, 2012, wer...